ITD-1


CAS No. : 1099644-42-4

ITD-1,1099644-42-4
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000412
Molecular Formula:C₂₇H₂₉NO₃
Molecular Weight:415.52
Target:TGFβ
IC50:0.85 μM
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Appearance:Solid powder
Purity: > 98%
Cat No:I000412
Cas No:1099644-42-4
Product-Name:ITD-1
InChI:InChI=1S/C27H29NO3/c1-5-31-26(30)23-17(2)28-21-15-27(3,4)16-22(29)25(21)24(23)20-13-11-19(12-14-20)18-9-7-6-8-10-18/h6-14,24,28H,5,15-16H2,1-4H3
InChIKey:ULFUJLFTRWWLPO-UHFFFAOYSA-N
SMILES:O=C(C1=C(C)NC2=C(C(CC(C)(C)C2)=O)C1C3=CC=C(C4=CC=CC=C4)C=C3)OCC

ITD-1 is an inducer of TGFβ type II receptor degradation-1, is a potent and highly selective TGFβ pathway inhibitor (IC50 = 0.85 μM).
IC50 value: 0.85 μM
Target: TGFβ
in vitro: ITD-1 selectively enhances the differentiation of uncommitted mesoderm to cardiomyocytes, but not to vascular smooth muscle and endothelial cells. ITD-1 is the first selective TGFβ inhibitor and reveals an unexpected role for TGFβ signaling in controlling cardiomyocyte differentiation from multipotent cardiovascular precursors. ITD-1 downregulates HA-TGFBR2 and TGFBR2-mCherry with nearly the same potency (IC50 = 1.05 and 1.31 μM, respectively). ITD-1 acts by enhancing degradation rather than by blocking synthesis, which would affect cell surface and intracellular receptor pools equally.


[1]. Willems E, et al. Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012 Aug 3;11(2):242-252.

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