PLpro inhibitor


CAS No. : 1093070-14-4

PLpro inhibitor,1093070-14-4
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000390
Synonyms:(Z)-5-((Z)-(1-hydroxyethylidene)amino)-2-methyl-N-((R)-1-(naphthalen-1-yl)ethyl)benzimidic acid
Molecular Formula:C22H22N2O2
Molecular Weight:346.42
Target:SARS-CoV
IC50:2.6 uM [1]
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Cat No:I000390
Cas No:1093070-14-4
Product-Name:PLpro inhibitor

PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with IC50 of 2.6 uM.
IC50 Value: 2.6 uM [1]
Target: PLpro; SARS-CoV
in vitro: PLpro inhibitor is a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro inhibitor was found to have IC50 value of 2.6 ± 0.1 μM. PLpro inhibitor display significant antiviral activity with EC50 values of 13.1±0.7 uM, without toxicity up to the highest concentration tested. Notably, the increasing antiviral potency correlates with the in vitro inhibition of PLpro, suggesting that the compounds work directly on the enzyme in cells [1,2].
in vivo:


[1]. Ratia, K., et al., A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A, 2008. 105(42): p. 16119-24.
[2]. http://www.google.com/patents/WO2010022355A1cl=en

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