PLpro inhibitor

CAS No. : 1093070-14-4

PLpro inhibitor,1093070-14-4
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000390
Synonyms:(Z)-5-((Z)-(1-hydroxyethylidene)amino)-2-methyl-N-((R)-1-(naphthalen-1-yl)ethyl)benzimidic acid
Molecular Formula:C22H22N2O2
Molecular Weight:346.42
IC50:2.6 uM [1]
Price:Get quote
We would like to match the lowest price on market if possible.

Your information is safe with us.

Cat No:I000390
Cas No:1093070-14-4
Product-Name:PLpro inhibitor

PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with IC50 of 2.6 uM.
IC50 Value: 2.6 uM [1]
Target: PLpro; SARS-CoV
in vitro: PLpro inhibitor is a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro inhibitor was found to have IC50 value of 2.6 ± 0.1 μM. PLpro inhibitor display significant antiviral activity with EC50 values of 13.1±0.7 uM, without toxicity up to the highest concentration tested. Notably, the increasing antiviral potency correlates with the in vitro inhibition of PLpro, suggesting that the compounds work directly on the enzyme in cells [1,2].
in vivo:

[1]. Ratia, K., et al., A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A, 2008. 105(42): p. 16119-24.

Recommended Products
  • CAS No. :103248-26-6
    Product Name:

    1H-Benzimidazole-1-methanamine, N-(4-ethoxyphenyl)-6-nitro-

    Cat No: M001273 View details
  • CAS No. :109522-29-4
    Product Name:

    5-fluoro-12-hydroxyeicosatetraenoic acid

    Cat No: M001274 View details
  • CAS No. :19997-54-7
    Product Name:


    Cat No: M001275 View details
  • CAS No. :19568-26-4
    Product Name:

    Tripropylammonium hexafluoroarsenate

    Cat No: M001276 View details