Pyridostatin


CAS No. : 1085412-37-8

Pyridostatin,1085412-37-8
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000370
Synonyms:4-(2-aminoethoxy)-2-N,6-N-bis[4-(2-aminoethoxy)quinolin-2-yl]pyridine-2,6-dicarboxamide
Molecular Formula:C31H32N8O5
Molecular Weight:596.6
Target:G-quadruplex
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Assay:≥95%
Appearance:A crystalline solid
Cat No:I000370
Cas No:1085412-37-8
Product-Name:Pyridostatin
InChIKey:VGHSATQVJCTKEF-UHFFFAOYSA-N

Pyridostatin(RR-82) is a G-quadruplex-interacting drug which can promote growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage.
IC50 Value:
Target: G-quadruplex
in vitro: The increased mechanical stability of pyridostatin-bound G-quadruplex permits the determination of a dissociation constant K(d) of 490 ± 80 nM. The free-energy change of binding obtained from a Hess-like process provides an identical K(d) for pyridostatin and a K(d) of 42 ± 3 uM for a weaker ligand RR110 [1]. Pyridostatin reduced SRC protein abundance and SRC-dependent cellular motility in human breast cancer cells, validating SRC as a target of this drug [2].
in vivo:
Clinical trial: N/A


[1]. Koirala D, Dhakal S, Ashbridge B, A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat Chem. 2011 Aug 28;3(10):782-7.
[2]. Rodriguez R, Miller KM, Forment JV, Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol. 2012 Feb 5;8(3):301-10.

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