ACT-462206


CAS No. : 1361321-96-1

ACT-462206,1361321-96-1
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000365
Synonyms:ACT-462206;(2S)-N-(3,5-dimethylphenyl)-1-(4-methoxyphenyl)sulfonylpyrrolidine-2-carboxamide
Molecular Formula:C20H24N2O4S
Molecular Weight:388.482
Price:Get quote
We would like to match the lowest price on market if possible.

Your information is safe with us.

refresh
Appearance:Solid powder
Purity: > 98%
Cat No:I000365
Cas No:1361321-96-1
Product-Name:ACT-462206
IUPAC Name:(2S)-N-(3,5-dimethylphenyl)-1-(4-methoxyphenyl)sulfonylpyrrolidine-2-carboxamide
InChI:InChI=1S/C20H24N2O4S/c1-14-11-15(2)13-16(12-14)21-20(23)19-5-4-10-22(19)27(24,25)18-8-6-17(26-3)7-9-18/h6-9,11-13,19H,4-5,10H2,1-3H3,(H,21,23)/t19-/m0/s1
InChIKey:NHPQGZOBHSVTAQ-IBGZPJMESA-N
SMILES:CC1=CC(=CC(=C1)NC(=O)C2CCCN2S(=O)(=O)C3=CC=C(C=C3)OC)C
ACT-462206 is an orally active, potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist.

1:Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist. Boss C, Roch-Brisbare C, Steiner MA, Treiber A, Dietrich H, Jenck F, von Raumer M, Sifferlen T, Brotschi C, Heidmann B, Williams JT, Aissaoui H, Siegrist R, Gatfield J.ChemMedChem. 2014 Nov;9(11):2486-96. doi: 10.1002/cmdc.201402258. Epub 2014 Aug 21. PMID: 25147058
2:Entry-into-humans study with ACT-462206, a novel dual orexin receptor antagonist, comparing its pharmacodynamics with almorexant. Hoch M, van Gorsel H, van Gerven J, Dingemanse J.J Clin Pharmacol. 2014 Sep;54(9):979-86. doi: 10.1002/jcph.297. Epub 2014 Apr 21. PMID: 24691844
Recommended Products
  • CAS No. :207446-92-2
    Product Name:

    Arteannuin N

    Cat No: R047233 View details
  • CAS No. :6519-27-3
    Product Name:

    (16R)-E-Isositsirikine

    Cat No: R047249 View details
  • CAS No. :82513-70-0
    Product Name:

    10-Hydroxy-16-epiaffinine

    Cat No: R047265 View details
  • CAS No. :852638-61-0
    Product Name:

    Heteronoside

    Cat No: R047298 View details