G418 Sulfate


CAS No. : 108321-42-2

G418 Sulfate,108321-42-2
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000364
Synonyms:2-[4,6-diamino-3-[3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid
Molecular Formula:C₂₀H₄₀N₄O₁₀. 2 H₂SO₄
Molecular Weight:692.71
Target:Antibiotic
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Form:Powder
Source:Biosynthetic: produced by Micromonospora rhodorangea.
Absorbance:1mg/ml (water): 280nm <0.015 570nm <0.01 100mg/ml (water): 570nm <0.01 1.74g/25 ml (water): 280nm <0.7
pH:4.6-6.0
Cat No:I000364
Cas No:108321-42-2
Product-Name:G418 Sulfate
MDL No:MFCD00058314
InChI:InChI=1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4)
InChIKey:UHEPSJJJMTWUCP-UHFFFAOYSA-N
SMILES:CC(C1C(C(C(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O

G418 (Geneticin) is an aminoglycoside antibiotic similar in structure to gentamicin B1; blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells.
IC50 value:
Target:
G-418 is an aminoglycoside related to Gentamicin, and is commonly used as a selective agent for eukaryotic cells. As an analog of neomycin sulfate, it interferes with the function of 80S ribosomes and protein synthesis in eukaryotic cells.


[1]. G-418, From Wikipedia

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