For research use only. Not Intended for Therapeutic Use!
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α-Lipoic Acid, a natural product, is reported to have antioxidative property.
In vitro: The effects of α-Lipoic Acid on thioacetamide-induced liver fibrosis in rats and the possible underlying mechanisms in hepatic stellate cells in vitro was examined. Co-administration of α-Lipoic Acid to rats chronically treated with TAA inhibited the development of liver cirrhosis, as indicated by reductions in cirrhosis incidence, hepatic fibrosis, and AST/ALT activities .
In vivo: In the study on the antioxidative activity of α-Lipoic Acid, the result showed that on the micronutrient functions of α-Lipoic Acid may be more as an effector of important cellular stress response pathways that ultimately influence endogenous cellular antioxidant levels and reduce proinflammatory mechanisms . α-Lipoic Acid exerts antioxidant effects in biological systems through ROS quenching but also via an action on transition metal chelation. Dietary supplementation with α-Lipoic Acid has been successfully employed in a variety of in vivo models of disease associated with an imbalance of redox status: diabetes and cardiovascular diseases .
. Kate Petersen Shay, et al. Is α-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity. IUBMB Life , Volume 60, Issue 6, pages 362–367, June 2008
. Antioxidant, et al. Direct and indirect antioxidant properties of α-lipoic acid and therapeutic potential. Molecular Nutrition & Food Research Volume 57, Issue 1, pages 114–125, January 2013
. Ning-Ping Foo, et al. α-Lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-β. Toxicology Volume 282, Issues 1–2, 28 March 2011, Pages 39–46