LDC000067


CAS No. : 1073485-20-7

LDC000067,1073485-20-7
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000339
Synonyms:(3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methanesulfonamide
Molecular Formula:C18H18N4O3S
Molecular Weight:370.43
Target:Cyclin-Dependent Kinases
IC50:32.7 nM [1]
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Cat No:I000339
Cas No:1073485-20-7
Product-Name:LDC000067

LDC000067(LDC-067) is a highly specific CDK9 inhibitor with IC50 of 32.7 nM for CDK9/cyclin T1; displays 55/125/210/ >227/ >227-fold selectivity for CDK9 versus CDK2/1/4/6/7.
IC50 value: 32.7 nM [1]
Target: CDK9 inhibitor
The selectivity of LDC000067 for CDK9 over other CDKs exceeded that of the known inhibitors flavopiridol and DRB. LDC000067 inhibited in vitro transcription in an ATP-competitive and dose-dependent manner. Gene expression profiling of cells treated with LDC000067 demonstrated a selective reduction of short-lived mRNAs, including important regulators of proliferation and apoptosis. LDC000067 represents a promising lead for the development of clinically useful, highly specific CDK9 inhibitors.


[1]. Albert TK, et al. Characterization of molecular and cellular functions of the cyclin-dependent kinase CDK9 using a novel specific inhibitor. Br J Pharmacol. 2014 Jan;171(1):55-68.

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