A-893


CAS No. : 1868232-32-9

A-893,1868232-32-9
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000327
Synonyms:A-893; A 893; A893.;(R)-N-cyclohexyl-3-((3,4-dichlorophenethyl)amino)-N-(2-((2-hydroxy-2-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)amino)ethyl)propanamide
Molecular Formula:C29H38Cl2N4O4
Molecular Weight:577.547
Target:SMYD2 inhibitor
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Appearance:Solid powder
Purity: > 98%
Cat No:I000327
Cas No:1868232-32-9
Product-Name:A-893
InChI:InChI=1S/C29H38Cl2N4O4/c30-23-10-9-20(17-24(23)31)11-13-32-14-12-28(38)35(21-5-2-1-3-6-21)16-15-33-18-26(36)22-7-4-8-25-29(22)39-19-27(37)34-25/h4,7-10,17,21,26,32-33,36H,1-3,5-6,11-16,18-19H2,(H,34,37)/t26-/m0/s1
InChIKey:WVRBXBROEPXZHF-SANMLTNESA-N
SMILES:O=C(N1)COC(C1=CC=C2)=C2[C@@H](O)CNCCN(C3CCCCC3)C(CCNCCC4=CC(Cl)=C(Cl)C=C4)=O
A-893 is a potent and selective SMYD2 inhibitor (IC50: 2.8 nM). A cocrystal structure reveals the origin of enhanced potency, and effective suppression of p53K370 methylation is observed in a lung carcinoma (A549) cell line.
1:ACS Med Chem Lett. 2015 Apr 29;6(6):695-700. doi: 10.1021/acsmedchemlett.5b00124. eCollection 2015 Jun 11. Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2.Sweis RF,Wang Z,Algire M,Arrowsmith CH,Brown PJ,Chiang GG,Guo J,Jakob CG,Kennedy S,Li F,Maag D,Shaw B,Soni NB,Vedadi M,Pappano WN, PMID: 26101576 PMCID: PMC4468393 DOI: 10.1021/acsmedchemlett.5b00124
Abstract: A lack of useful small molecule tools has precluded thorough interrogation of the biological function of SMYD2, a lysine methyltransferase with known tumor-suppressor substrates. Systematic exploration of the structure-activity relationships of a previously known benzoxazinone compound led to the synthesis of A-893, a potent and selective SMYD2 inhibitor (IC50: 2.8 nM). A cocrystal structure reveals the origin of enhanced potency, and effective suppression of p53K370 methylation is observed in a lung carcinoma (A549) cell line.
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