A-841720


CAS No. : 869802-58-4

A-841720,869802-58-4
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000318
Synonyms:A-841720;9-(Dimethylamino)-3-(hexahydro-1H-azepin-1-yl)-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-one
Molecular Formula:C17H21N5OS
Molecular Weight:343.449
Target:GluR
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Appearance:Solid powder
Purity: > 98%
Cat No:I000318
Cas No:869802-58-4
Product-Name:A-841720
IUPAC Name:3-(azepan-1-yl)-9-(dimethylamino)pyrido[1,2]thieno[3,4-d]pyrimidin-4-one
InChI:InChI=1S/C17H21N5OS/c1-20(2)12-7-8-18-16-13(12)14-15(24-16)17(23)22(11-19-14)21-9-5-3-4-6-10-21/h7-8,11H,3-6,9-10H2,1-2H3
InChIKey:GYWGXEGOXODOQU-UHFFFAOYSA-N
SMILES:CN(C)C1=C2C3=C(C(=O)N(C=N3)N4CCCCCC4)SC2=NC=C1
A-841720 is a metabotropic glutamate receptor 1 antagonist.

1:Comparison of the mGluR1 antagonist A-841720 in rat models of pain and cognition. Morè L, Gravius A, Pietraszek M, Belozertseva I, Malyshkin A, Shekunova E, Barberi C, Schaefer D, Schmidt WJ, Danysz W.Behav Pharmacol. 2007 Jul;18(4):273-81. PMID: 17551319
2:Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist. El-Kouhen O, Lehto SG, Pan JB, Chang R, Baker SJ, Zhong C, Hollingsworth PR, Mikusa JP, Cronin EA, Chu KL, McGaraughty SP, Uchic ME, Miller LN, Rodell NM, Patel M, Bhatia P, Mezler M, Kolasa T, Zheng GZ, Fox GB, Stewart AO, Decker MW, Moreland RB, Brioni JD, Honore P.Br J Pharmacol. 2006 Nov;149(6):761-74. Epub 2006 Oct 3. PMID: 17016515 Free PMC Article
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