For research use only. Not Intended for Therapeutic Use!
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Ginsenoside Rh3, metabolized from ginsenoside Rg5 which is isolated from red ginseng can be anti-inflammatory.
In vitro: Ginsenoside Rh3 can induce differentiation of HL-60 cells into granulocytes and modulation of PKC isoform levels may contribute to differentiation of HL-60 cells by G-Rh2 .
In vivo: Ginsenoside Rh3 suppressed swelling of oxazolone-induced mouse ear contact dermatitis, reduced mRNA expressions of cyclooxygenase-2, interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma .
. Shin YW, et al. Inhibitory effect of ginsenoside Rg5 and its metabolite ginsenoside Rh3 in an oxazolone-induced mouse chronic dermatitis model. Arch Pharm Res. 2006 Aug;29(8):685-90.
. Kim YS, et al. Ginsenoside Rh2 and Rh3 induce differentiation of HL-60 cells into granulocytes: modulation of protein kinase C isoforms during differentiation by ginsenoside Rh2. The international journal of biochemistry & cell biology, 1998, 30 (3): 327-338