SBE13 hydrochloride


CAS No. : 1052532-15-6

SBE13 hydrochloride,1052532-15-6
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000284
Synonyms:N-(4-((6-chloropyridin-3-yl)methoxy)-3-methoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanamine hydrochloride
Molecular Formula:C₂₄H₂₇ClN₂O₄.HCl
Molecular Weight:479.4
Target:PLK
IC50:0.2 nM [1]
Price:Get quote
We would like to match the lowest price on market if possible.

Your information is safe with us.

refresh
Appearance:white solid powder
Purity: > 98%
Cat No:I000284
Cas No:1052532-15-6
Product-Name:SBE13 hydrochloride
MDL No:MFCD20036266
InChI:InChI=1S/C24H27ClN2O4.ClH/c1-28-20-7-4-17(12-22(20)29-2)10-11-26-14-18-5-8-21(23(13-18)30-3)31-16-19-6-9-24(25)27-15-19;/h4-9,12-13,15,26H,10-11,14,16H2,1-3H3;1H
InChIKey:QBGSVDJLQQXEGG-UHFFFAOYSA-N
SMILES:COC1=C(C=C(C=C1)CCNCC2=CC(=C(C=C2)OCC3=CN=C(C=C3)Cl)OC)OC.Cl

SBE13 Hcl is a potent and selective PLK1 with IC50 of 0.2 nM; no inhibition om Aurora A kinase, Plk2 and Plk3.
IC50 value: 0.2 nM [1]
Target: PLK1 inhibitor
in vitro: To test the selectivity of SBE13 for Plk1 we probed its inhibitory effect on aurora A kinase, Plk2, and Plk3. No decrease in aurora A kinase activity was observed, and only marginally decreased Plk2 (IC50>66μm) or Plk3 (IC50=875 nm) kinase activity was detected after 13 h release in the presence of SBE13 (p>0.05) [1]. Plk1 inhibition using SBE13 enhances the effects of Enzastaurin in cancer cells. HCT116(p53wt) and HCT116(p53-/-) cells confirmed the p53-dependence of different effects after Plk1 and PKCβ inhibition observed in HeLa and MCF-7 cells. Obviously, p53 protects cells from the cytotoxicity of Enzastaurin in combination with SBE13 [2].


[1]. Keppner S, et al. Identification and validation of a potent type II inhibitor of inactive polo-like kinase 1. ChemMedChem. 2009 Nov;4(11):1806-9.
[2]. Lange L, et al. Combinatorial inhibition of Plk1 and PKCβ in cancer cells with different p53 status. Oncotarget. 2014 Apr 30;5(8):2263-75.
[3]. Keppner S, et al. Biological impact of freezing Plk1 in its inactive conformation in cancer cells. Cell Cycle. 2010 Feb 15;9(4):761-73.

Related Products
  • CAS No. :1228960-69-7
    Product Name:

    MLN0905

    Cat No: I000899 View details
  • CAS No. :1062243-51-9
    Product Name:

    Ro3280

    Cat No: I000314 View details
  • CAS No. :755038-65-4
    Product Name:

    BI 6727

    Cat No: I004793 View details
  • CAS No. :173529-46-9
    Product Name:

    HMN-214

    Cat No: I002261 View details