A-438079 HCl

CAS No. : 899431-18-6 (HCl)

A-438079 HCl,899431-18-6 (HCl)
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000283
Synonyms:A-438079 ; A 438079; A438079; A-438079 HCl.;3-((5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methyl)pyridine hydrochloride
Molecular Formula:C13H10Cl3N5
Molecular Weight:342.608
Target:P2X7 receptor antagonist
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Appearance:Solid powder
Purity: > 98%
Cat No:I000283
Cas No:899431-18-6 (HCl)
Product-Name:A-438079 HCl
Related Cas:899507-36-9 (free base)
IUPAC Name:3-[[5-(2,3-dichlorophenyl)tetrazol-1-yl]methyl]pyridine;hydrochloride

A-438079 HCl (cas 899431-18-6) is a P2X7 receptor antagonist. 

A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation. A-438079 partially but significantly prevented the 6-OHDA-induced depletion of striatal DA stores. P2X7R inhibitor A-438079 reduced electrographic and clinical seizure severity during status epilepticus and reduced seizure-induced neuronal death in the neocortex. Blockade of P2X(7) receptors may represent a novel protective strategy for striatal DA terminals in Parkinson/'s disease.

1: Jimenez-Pacheco A, Mesuret G, Sanz-Rodriguez A, Tanaka K, Mooney C, Conroy R, Miras-Portugal MT, Diaz-Hernandez M, Henshall DC, Engel T. Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079. Epilepsia. 2013 Sep;54(9):1551-61. doi: 10.1111/epi.12257. Epub 2013 Jun 28. PubMed PMID: 23808395.
2: Marcellino D, Suárez-Boomgaard D, Sánchez-Reina MD, Aguirre JA, Yoshitake T, Yoshitake S, Hagman B, Kehr J, Agnati LF, Fuxe K, Rivera A. On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson/'s disease: studies with the P2X(7) receptor antagonist A-438079. J Neural Transm (Vienna). 2010 Jun;117(6):681-7. doi: 10.1007/s00702-010-0400-0. Epub 2010 Apr 13. PubMed PMID: 20387084.
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