CAS No. : 104987-11-3

Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000276
Molecular Formula:C₄₄H₆₉NO₁₂
Molecular Weight:804.02
IC50:0.47 nM (Inhibition of lymphocyte proliferation)
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Appearance: White powder
Melting Point: 871.7°C
Loss on Drying: ≤3.0%
Cat No:I000276
Cas No:104987-11-3
MDL No:MFCD11045918

Tacrolimus(cas 104987-11-3) is a potent immunosuppressive drug often administered to transplant recipient patients and exhibits a variety of adverse cardiovascular effects.

Clinical trial: PK Tacrolimus in Transplants. Phase 4

1: Jusko WJ, Kobayashi M. Therapeutic monitoring of tacrolimus (FK 506). Ther Drug Monit. 1993 Aug;15(4):349. PubMed PMID: 7694395.
2: Piekoszewski W, Chow FS, Jusko WJ. Disposition of tacrolimus (FK 506) in rabbits. Role of red blood cell binding in hepatic clearance. Drug Metab Dispos. 1993 Jul-Aug;21(4):690-8. PubMed PMID: 7690698.
3: Piekoszewski W, Jusko WJ. Plasma protein binding of tacrolimus in humans. J Pharm Sci. 1993 Mar;82(3):340-1. PubMed PMID: 7680714.
4: Jegasothy BV, Ackerman CD, Todo S, Fung JJ, Abu-Elmagd K, Starzl TE. Tacrolimus (FK 506)--a new therapeutic agent for severe recalcitrant psoriasis. Arch Dermatol. 1992 Jun;128(6):781-5. PubMed PMID: 1376102; PubMed Central PMCID: PMC3208344.
5: Min DI, Brown T, Hwang GC. Visual compatibility of tacrolimus with commonly used drugs during simulated Y-site injection. Am J Hosp Pharm. 1992 Dec;49(12):2964-6. PubMed PMID: 1282779.
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