UPF 1069


CAS No. : 1048371-03-4

UPF 1069,1048371-03-4
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000270
Synonyms:5-phenacyloxy-2H-isoquinolin-1-one
Target:PARP
IC50:0.3 μM
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Appearance:Solid powder
Purity: > 98%
Cat No:I000270
Cas No:1048371-03-4
Product-Name:UPF 1069

UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM; ~27-fold selective against PARP1.
IC50 Value: 0.3 μM
Target: PARP2
in vitro: In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 micromolxL(-1)) caused a concentration-dependent exacerbation (up to 155%) of OGD-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, had no effect on OGD injury [1].
in vivo: In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 mM) causes a concentration-dependent exacerbation (up to 155%) of oxygen-glucose deprivation (OGD)-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, have no effect on OGD injury. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage.
Clinical trial: N/A


[1]. Moroni F, Formentini L, Gerace E, Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. Br J Pharmacol. 2009 Jul;157(5):854-62.

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