Afuresertib hydrochloride


CAS No. : 1047645-82-8

Afuresertib hydrochloride,1047645-82-8
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000266
Synonyms:GSK2110183B
Molecular Formula:C₁₈H₁₇Cl₂FN₄OS • HCl
Molecular Weight:463.8
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Assay:≥98%
Appearance:A crystalline solid
Cat No:I000266
Cas No:1047645-82-8
Product-Name:Afuresertib hydrochloride
InChI:InChI=1S/C18H17Cl2FN4OS.ClH/c1-25-16(14(19)9-23-25)13-7-15(27-17(13)20)18(26)24-12(8-22)6-10-3-2-4-11(21)5-10;/h2-5,7,9,12H,6,8,22H2,1H3,(H,24,26);1H/t12-;/m0./s1
InChIKey:YFQJOPFTGMHYNV-YDALLXLXSA-N
SMILES:CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=CC=C3)F)CN)Cl.Cl

Afuresertib Hcl (GSK2110183 Hcl) is a potent pan-AKT inhibitor that demonstrated synergy with bortezomib in preclinical models of multiple myeloma (MM).


[1]. Spencer A, et al. Novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma: Phase 1 study results. Blood. 2014 Jul 29. pii: blood-2014-03-559963.

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