CAS No. : 1047644-62-1
| Product Details | |
|---|---|
For research use only. Not Intended for Therapeutic Use! | |
| Cat No: | I000265 |
| Synonyms: | N-[(2S)-1-amino-3-(3-fluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)thiophene-2-carboxamide |
| Molecular Formula: | C₁₈H₁₇Cl₂F₂N₄OS |
| Molecular Weight: | 427.32 |
| Target: | PKB |
| Price: | Get quote |
| We would like to match the lowest price on market if possible. | |
| Cat No: | I000265 |
| Cas No: | 1047644-62-1 |
| Product-Name: | GSK-2110183 |
| InChI: | InChI=1S/C18H16Cl2F2N4OS/c1-26-16(12(19)8-24-26)11-6-15(28-17(11)20)18(27)25-10(7-23)4-9-2-3-13(21)14(22)5-9/h2-3,5-6,8,10H,4,7,23H2,1H3,(H,25,27)/t10-/m0/s1 |
| InChIKey: | AHDFWNJLFALBJP-JTQLQIEISA-N |
| SMILES: | CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=C(C=C3)F)F)CN)Cl |
Afuresertib (GSK2110183) is a potent pan-AKT inhibitor that demonstrated synergy with bortezomib in preclinical models of multiple myeloma (MM).
[1]. Spencer A, et al. Novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma: Phase 1 study results. Blood. 2014 Jul 29. pii: blood-2014-03-559963.
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