GSK-2110183


CAS No. : 1047644-62-1

GSK-2110183,1047644-62-1
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000265
Synonyms:N-[(2S)-1-amino-3-(3-fluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)thiophene-2-carboxamide
Molecular Formula:C₁₈H₁₇Cl₂F₂N₄OS
Molecular Weight:427.32
Target:PKB
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Cat No:I000265
Cas No:1047644-62-1
Product-Name:GSK-2110183
InChI:InChI=1S/C18H16Cl2F2N4OS/c1-26-16(12(19)8-24-26)11-6-15(28-17(11)20)18(27)25-10(7-23)4-9-2-3-13(21)14(22)5-9/h2-3,5-6,8,10H,4,7,23H2,1H3,(H,25,27)/t10-/m0/s1
InChIKey:AHDFWNJLFALBJP-JTQLQIEISA-N
SMILES:CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=C(C=C3)F)F)CN)Cl

Afuresertib (GSK2110183) is a potent pan-AKT inhibitor that demonstrated synergy with bortezomib in preclinical models of multiple myeloma (MM).


[1]. Spencer A, et al. Novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma: Phase 1 study results. Blood. 2014 Jul 29. pii: blood-2014-03-559963.

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