GSK2141795


CAS No. : 1047634-65-0

GSK2141795,1047634-65-0
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000263
Synonyms:N-((S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)furan-2-carboxamide
Molecular Formula:C18H16Cl2F2N4O2
Molecular Weight:429.2
Target:Akt
IC50:180/328/38 nM (Akt1/2/3)
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Assay:≥98%
Appearance:A crystalline solid
Cat No:I000263
Cas No:1047634-65-0
Product-Name:GSK2141795
InChIKey:AXTAPYRUEKNRBA-JTQLQIEISA-N

GSK2141795 is a potent and selective pan-Akt inhibitor with IC50 values of 180 nM for Akt1, 328 nM for Akt2, and 38 nM for Akt3 respectively (Clinical phase 1).
IC50 value: 180/328/38 nM (Akt1/2/3)
Target: pan-Akt inhibitor
KD values of 16 nM for Akt1, 49 nM for Akt2, and 5 nM for Akt3 (for GSK2141795), which are in line with literature data from biochemical assays that report potencies of 2 nM for Akt1, 2-13 nM for Akt2, and 3-9 nM Akt3 for GSK690693.


[1]. Pachl F, et al. Characterization of a chemical affinity probe targeting Akt kinases. J Proteome Res. 2013 Aug 2;12(8):3792-800.

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