CAS No. : 1045792-66-2

Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000254
Synonyms:N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-1,1-dimethylethyl ester, carbamic acid
Molecular Formula:C22H30N4O6
Molecular Weight:446.5
Target:HDAC6 inhibitor
IC50:2 pM [1]
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Appearance:Solid powder
Purity: > 98%
Cat No:I000254
Cas No:1045792-66-2

CAY10603 is a potent and selective inhibitor of HDAC6 with IC50 of 2 pM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively.
IC50 value: 2 pM [1]
Target: HDAC6 inhibitor
CAY10603 prevents the growth of several pancreatic cancer cell lines (IC50 = 0.1-1 μM). The HDAC6 inhibitor is more active in inhibiting cell growth than the broad spectrum HDAC inhibitor suberoylanilide hydroxamic acid (SAHA).

[1]. Kozikowski AP, et al. Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. J Med Chem. 2008 Aug 14;51(15):4370-3.

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