CAS No. : 10457-90-6

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For research use only. Not Intended for Therapeutic Use!
Cat No:I000253
Molecular Formula:C21H23BrFNO2
Molecular Weight:420.32
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Appearance:Solid powder
Purity: > 98%
Cat No:I000253
Cas No:10457-90-6

Bromperidol is a butyrophenone derivative, is a potent and long-acting neuroleptic, used as an antipsychotic in the treatment of schizophrenia.

1:Comparison of the anti-dopamine D₂ and anti-serotonin 5-HT(2A) activities of chlorpromazine, bromperidol, haloperidol and second-generation antipsychotics parent compounds and metabolites thereof. Suzuki H, Gen K, Inoue Y.J Psychopharmacol. 2013 Apr;27(4):396-400. doi: 10.1177/0269881113478281. Epub 2013 Feb 20. PMID: 23427194
2:Bromperidol decanoate (depot) for schizophrenia. Purgato M, Adams CE.Cochrane Database Syst Rev. 2012 Nov 14;11:CD001719. doi: 10.1002/14651858.CD001719.pub4. Review. PMID: 23152208
3:Bromperidol decanoate (depot) for schizophrenia. Purgato M, Adams CE.Cochrane Database Syst Rev. 2011 Sep 7;(9):CD001719. doi: 10.1002/14651858.CD001719.pub3. Review. Update in: Cochrane Database Syst Rev. 2012;11:CD001719. PMID: 21901678
4:Number needed to treat and number needed to harm with paliperidone palmitate relative to long-acting haloperidol, bromperidol, and fluphenazine decanoate for treatment of patients with schizophrenia. Gopal S, Berwaerts J, Nuamah I, Akhras K, Coppola D, Daly E, Hough D, Palumbo J.Neuropsychiatr Dis Treat. 2011;7:93-101. doi: 10.2147/NDT.S17177. Epub 2011 Mar 8. PMID: 21552311 Free PMC Article
5:Sensitive determination of 4-(4-bromophenyl)-4-hydroxypiperidine, a metabolite of bromperidol, in rat plasma by HPLC with fluorescence detection after pre-column derivatization using 4-fluoro-7-nitro-2,1,3-benzoxadiazole. Higashi Y, Nakamura S, Fujii Y.Biol Pharm Bull. 2006 Dec;29(12):2479-82. PMID: 17142985 Free Article
6:Pharmacokinetic parameters of bromperidol in Korean subjects. Lee SY, Kim YG, Kim HG, Kim JW.Hum Psychopharmacol. 2006 Aug;21(6):409-12. PMID: 16915578
7:Association between multidrug resistance 1 (MDR1) gene polymorphisms and therapeutic response to bromperidol in schizophrenic patients: a preliminary study. Yasui-Furukori N, Saito M, Nakagami T, Kaneda A, Tateishi T, Kaneko S.Prog Neuropsychopharmacol Biol Psychiatry. 2006 Mar;30(2):286-91. Epub 2006 Jan 4. PMID: 16386826
8:Depot bromperidol decanoate for schizophrenia. Wong D, Adams CE, David A, Quraishi SN.Cochrane Database Syst Rev. 2004;(3):CD001719. Review. Update in: Cochrane Database Syst Rev. 2011;(9):CD001719. PMID: 15266450
9:Establishment of new cloned enzyme donor immunoassays (CEDIA) for haloperidol and bromperidol. Yasui-Furukori N, Saito M, Furukori H, Inoue Y, Someya T, Kaneko S, Tateishi T.Ther Drug Monit. 2004 Jun;26(3):336-41. PMID: 15167638
10:Simultaneous determination of haloperidol and bromperidol and their reduced metabolites by liquid-liquid extraction and automated column-switching high-performance liquid chromatography. Yasui-Furukori N, Inoue Y, Chiba M, Tateishi T.J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Jun 5;805(1):175-80. PMID: 15113555
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