CAS No. : 1043797-53-0

RU-SKI 43,1043797-53-0
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000249
Molecular Formula:C22H30N2O2S
Molecular Weight:386.55
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Cat No:I000249
Cas No:1043797-53-0
Product-Name:RU-SKI 43

RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.
IC50 value:
Target: Hhat inhibitor
RU-SKI 43 reduced pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling. In addition, RU-SKI 43 treatment inhibited two key proliferative pathways regulated by Akt and mTOR.

[1]. Petrova E, et al. Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene. 2014 Jan 27. doi: 10.1038/onc.2013.575.

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