(±)-Bisoprolol hemifumarate


CAS No. : 104344-23-2

(±)-Bisoprolol hemifumarate,104344-23-2
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000247
Synonyms:(E)-but-2-enedioic acid;1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol
Molecular Formula:C22H35NO8
Molecular Weight:441.52
Target:Adrenergic Receptor
Price:Get quote
We would like to match the lowest price on market if possible.

Your information is safe with us.

refresh
Appearance:Solid powder
Purity: > 98%
Cat No:I000247
Cas No:104344-23-2
Product-Name:(±)-Bisoprolol hemifumarate

Bisoprolol is a selective type β1 adrenergic receptor blocker.
Target: Adrenergic Receptor
Approved: July 31, 1992
Bisoprolol, on beta 1-adrenoceptor peptide induced autoimmune myocardial damage. In the animal model of autoimmune cardiomyopathy induced by active immunization of rabbits with beta 1-adrenoceptor peptide, bisoprolol was given at a dose of 3 mg/day throughout the study period. Our results showed high titer of anti-beta 1-adrenoceptor antibody in the immunized group throughout the study but not in the group receiving only bisoprolol [1]. Bisoprolol administration resulted in a significant reduction in HR reaching 60.3 +/- 1.4 bpm at VT of 500 mL (compared to 70.5 +/- 1.8 bpm with placebo, P < 0.001). Changes in HP were also significant with an increase in HP reaching 1004.5 +/- 22.2 msec at this controlled VT (compared to 860.3 +/- 21.5 msec with placebo, P < 0.001) [2].
Toxicity: Oral, mouse: LD50 = 100 mg/kg; Skin, rabbit: LD50 = 200 mg/kg; Skin, rat: LD50 = 500 mg/kg. Symptoms of overdose include congestive heart failure (marked by sudden weight gain, swelling of the legs, feet, and ankles, fatigue, and shortness of breath), difficult or labored breathing, low blood pressure, low blood sugar, and slow heartbeat.


[1]. Matsui, S., et al., Protective effect of bisoprolol on beta-1 adrenoceptor peptide-induced autoimmune myocardial damage in rabbits. Herz, 2000. 25(3): p. 267-70.
[2]. Wargon, M., et al., Acute effects of bisoprolol on respiratory sinus arrhythmia. Fundam Clin Pharmacol, 1998. 12(4): p. 451-6.

Related Products
  • CAS No. :55-31-2
    Product Name:

    Epinephrine HCl

    Cat No: A000523 View details
  • CAS No. :80259-18-3
    Product Name:

    JP 1302 dihydrochloride

    Cat No: I011425 View details
  • CAS No. :7361-61-7
    Product Name:

    Xylazine

    Cat No: I004735 View details
  • CAS No. :63-92-3
    Product Name:

    Phenoxybenzamine HCl

    Cat No: A000370 View details