Eicosapentaenoic Acid

CAS No. : 10417-94-4

Eicosapentaenoic Acid,10417-94-4
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000242
Synonyms:Single-Use EPA (peroxide free);Single-Use Timnodonic Acid (peroxide free)
Molecular Formula:C20H30O2
Molecular Weight:302.5
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Unit:25 mg
Physical Appearance:liquid
Cat No:I000242
Cas No:10417-94-4
Product-Name:Eicosapentaenoic Acid

Eicosapentaenoic acid (EPA) is an omega-3 fatty acid.
Target: Others
Studies have suggested that EPA may be efficacious in treating depression. One 2004 study, took blood samples of 100 suicide attempt patients and compared the blood samples to those of controls and found that levels of eicosapentaenoic acid were significantly lower in the washed red blood cells of the suicide-attempt patients. A 2009 metastudy found that patients taking omega-3 supplements with a higher EPA:DHA ratio experienced fewer depressive symptoms. One study also reports the remission of depressive symptoms and decrease in lateral ventricular volume of a patient who suffers from chronic fatigue syndrome after taking high-EPA essential fatty acid supplement [1, 2].

1:Dietary eicosapentaenoic acid normalizes hippocampal omega-3 and 6 polyunsaturated fatty acid profile, attenuates glial activation and regulates BDNF function in a rodent model of neuroinflammation induced by central interleukin-1β administration. Dong Y, Xu M, Kalueff AV, Song C.Eur J Nutr. 2017 May 18. doi: 10.1007/s00394-017-1462-7. [Epub ahead of print] PMID: 28523372
2:Supplementation with high-dose docosahexaenoic acid increases the Omega-3 Index more than high-dose eicosapentaenoic acid. Allaire J, Harris WS, Vors C, Charest A, Marin J, Jackson KH, Tchernof A, Couture P, Lamarche B.Prostaglandins Leukot Essent Fatty Acids. 2017 May;120:8-14. doi: 10.1016/j.plefa.2017.03.008. Epub 2017 Mar 31. PMID: 28515020
3:Eicosapentaenoic acid shows anti-inflammatory effect via GPR120 in 3T3-L1 adipocytes and attenuates adipose tissue inflammation in diet-induced obese mice. Yamada H, Umemoto T, Kakei M, Momomura SI, Kawakami M, Ishikawa SE, Hara K.Nutr Metab (Lond). 2017 May 8;14:33. doi: 10.1186/s12986-017-0188-0. eCollection 2017. PMID: 28503189 Free PMC Article
4:Minimal food effect for eicosapentaenoic acid and docosahexaenoic acid bioavailability from omega-3-acid ethyl esters with an Advanced Lipid TechnologiesTM (ALT®)-based formulation. Lopez-Toledano MA, Thorsteinsson T, Daak AA, Maki KC, Johns C, Rabinowicz AL, Sancilio FD.J Clin Lipidol. 2017 Mar - Apr;11(2):394-405. doi: 10.1016/j.jacl.2017.01.017. Epub 2017 Feb 9. PMID: 28502496
5:Eicosapentaenoic acid monoglyceride resolves inflammation in an ex vivo model of human peripheral blood mononuclear cell. Morin C, Charbonneau L, Ouellet N, Ouellet H, Blier PU, Dufresne F, Fortin S.Eur J Pharmacol. 2017 May 10. pii: S0014-2999(17)30336-9. doi: 10.1016/j.ejphar.2017.05.018. [Epub ahead of print] PMID: 28501579
6:Eicosapentaenoic Acid Downregulates Expression of the Selenoprotein P Gene by Inhibiting SREBP-1c Independently of the AMPK Pathway in H4IIEC3 Hepatocytes. Tajima-Shirasaki N, Ishii KA, Takayama H, Shirasaki T, Iwama H, Chikamoto K, Saito Y, Iwasaki Y, Teraguchi A, Lan F, Kikuchi A, Takeshita Y, Murao K, Matsugo S, Kaneko S, Misu H, Takamura T.J Biol Chem. 2017 May 2. pii: jbc.M116.747006. doi: 10.1074/jbc.M116.747006. [Epub ahead of print] PMID: 28465347 Free Article
7:A novel liquid chromatography/tandem mass spectrometry (LC-MS/MS) based bioanalytical method for quantification of ethyl esters of Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) and its application in pharmacokinetic study. Viswanathan S, Verma PRP, Ganesan M, Manivannan J.J Pharm Biomed Anal. 2017 Jul 15;141:250-261. doi: 10.1016/j.jpba.2017.04.002. Epub 2017 Apr 8. PMID: 28463780
8:Evaluation of the stabilizing effect of eicosapentaenoic acid therapy on coronary atherosclerotic plaques using optical coherence tomography; meta-analysis. Mousa M, Meshref A.Atheroscler Suppl. 2017 Mar;25:e6. doi: 10.1016/j.atherosclerosissup.2017.03.011. No abstract available. PMID: 28452312
9:A Study of the Differential Effects of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Gene Expression Profiles of Stimulated Thp-1 Macrophages. Allam-Ndoul B, Guénard F, Barbier O, Vohl MC.Nutrients. 2017 Apr 25;9(5). pii: E424. doi: 10.3390/nu9050424. PMID: 28441337 Free Article
10:Quantitative proteomics reveals key proteins regulated by eicosapentaenoic acid in endothelial activation. Zhang L, Xiao K, Zhao X, Sun X, Zhang J, Wang X, Zhu Y, Zhang X.Biochem Biophys Res Commun. 2017 May 27;487(2):464-469. doi: 10.1016/j.bbrc.2017.04.091. Epub 2017 Apr 18. PMID: 28431930
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