CAS No. : 556835-30-4

Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000236
Synonyms:A-349821;(1,5-diacetyloxy-3,4-dimethoxyhexan-2-yl) acetate
Molecular Formula:C28H35F3N2O5
Molecular Weight:536.592
Target:H3 receptor agonist radioligand
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Appearance:Solid powder
Purity: > 98%
Cat No:I000236
Cas No:556835-30-4
IUPAC Name:[4-[4-[3-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]propoxy]phenyl]phenyl]-morpholin-4-ylmethanone;2,2,2-trifluoroacetic acid
A-349821 is an H3 receptor agonist radioligand.

1:Use of the H3 receptor antagonist radioligand [3H]-A-349821 to reveal in vivo receptor occupancy of cognition enhancing H3 receptor antagonists. Miller TR, Milicic I, Bauch J, Du J, Surber B, Browman KE, Marsh K, Cowart M, Brioni JD, Esbenshade TA.Br J Pharmacol. 2009 May;157(1):139-49. doi: 10.1111/j.1476-5381.2009.00239.x. PMID: 19413577 Free PMC Article
2:Detection of multiple H3 receptor affinity states utilizing [3H]A-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand. Witte DG, Yao BB, Miller TR, Carr TL, Cassar S, Sharma R, Faghih R, Surber BW, Esbenshade TA, Hancock AA, Krueger KM.Br J Pharmacol. 2006 Jul;148(5):657-70. Epub 2006 May 22. PMID: 16715122 Free PMC Article
3:Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist. Esbenshade TA, Fox GB, Krueger KM, Baranowski JL, Miller TR, Kang CH, Denny LI, Witte DG, Yao BB, Pan JB, Faghih R, Bennani YL, Williams M, Hancock AA.Biochem Pharmacol. 2004 Sep 1;68(5):933-45. PMID: 15294456
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