MBX-2982


CAS No. : 1037792-44-1

MBX-2982,1037792-44-1
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000225
Synonyms:2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole
Molecular Formula:C22H24N8OS
Molecular Weight:448.5
Target:GPR119
Price:Get quote
We would like to match the lowest price on market if possible.

Your information is safe with us.

refresh
Appearance:Solid powder
Purity: > 98%
Cat No:I000225
Cas No:1037792-44-1
Product-Name:MBX-2982
InChI:InChI=1S/C22H24N8OS/c1-2-16-11-23-22(24-12-16)29-9-7-17(8-10-29)21-26-18(14-32-21)13-31-20-5-3-19(4-6-20)30-15-25-27-28-30/h3-6,11-12,14-15,17H,2,7-10,13H2,1H3
InChIKey:NFTMKHWBOINJGM-UHFFFAOYSA-N
SMILES:CCC1=CN=C(N2CCC(C3=NC(COC4=CC=C(N5N=NN=C5)C=C4)=CS3)CC2)N=C1

MBX-2982 is a selective, orally-available GPR119 agonist for the treatment of type 2 tiabetes.
IC50 value:
Target: GPR119
MBX-2982 is a potential first-in-class treatment for type 2 diabetes that targets G protein-coupled receptor 119 (GPR119), a receptor that interacts with bioactive lipids known to stimulate glucose-dependent insulin secretion. Preclinical data indicate that MBX-2982 is a potent selective orally-active GPR119 agonist that functions through a unique dual mechanism of action. First, it acts directly on the beta cell to increase insulin secretion. In addition, MBX-2982 stimulates release of the incretin GLP-1 from the gut. This dual action is unique and may offer improved glucose homeostasis over existing diabetes therapies, with potential for weight loss and improved islet health.


[1]. BRIAN ROBERTS, FRANCINE M. GREGOIRE, DAVID B. KARPF et al. MBX-2982, a Novel Oral GPR119 Agonist for the Treatment of Type 2 Diabetes: Results of Single & Multiple Dose Studies.
[2]. Gater D. 32nd National Medicinal Chemistry Symposium--medicinal chemistry developments for neurodegeneration, diabetes and cancer. Drugs. 2010 Aug;13(8):514-6.
[3]. Jones RM, Leonard JN, Buzard DJ, Lehmann J. GPR119 agonists for the treatment of type 2 diabetes. Expert Opin Ther Pat. 2009 Oct;19(10):1339-59.

Related Products
  • CAS No. :330981-72-1
    Product Name:

    2-[[2-(4-Bromophenyl)-6-methyl-4-pyrinidinyl]amino]ethanol

    Cat No: R041585 View details
  • CAS No. :832714-46-2
    Product Name:

    APD668

    Cat No: I005002 View details
  • CAS No. :857652-30-3
    Product Name:

    PSN632408

    Cat No: I005154 View details
  • CAS No. :733750-99-7
    Product Name:

    AR 231453

    Cat No: I004729 View details