A-317920


CAS No. : 360551-59-3

A-317920,360551-59-3
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000214
Synonyms:A-317920;N-[(2R)-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-1-oxopropan-2-yl]furan-2-carboxamide
Molecular Formula:C25H31N3O5
Molecular Weight:453.539
Target:inverse agonist radioligand
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Appearance:Solid powder
Purity: > 98%
Cat No:I000214
Cas No:360551-59-3
Product-Name:A-317920
IUPAC Name:N-[(2R)-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-1-oxopropan-2-yl]furan-2-carboxamide
InChI:InChI=1S/C25H31N3O5/c1-18(26-24(30)22-4-2-16-33-22)25(31)28-14-12-27(13-15-28)11-3-17-32-21-9-7-20(8-10-21)23(29)19-5-6-19/h2,4,7-10,16,18-19H,3,5-6,11-15,17H2,1H3,(H,26,30)/t18-/m1/s1
InChIKey:RTRADBQSZJIRMT-GOSISDBHSA-N
SMILES:CC(C(=O)N1CCN(CC1)CCCOC2=CC=C(C=C2)C(=O)C3CC3)NC(=O)C4=CC=CO4
A-317920 is an inverse agonist radioligand.

1:Use of an inverse agonist radioligand [3H]A-317920 reveals distinct pharmacological profiles of the rat histamine H3 receptor. Yao BB, Witte DG, Miller TR, Carr TL, Kang CH, Cassar S, Faghih R, Bennani YL, Surber BW, Hancock AA, Esbenshade TA.Neuropharmacology. 2006 Mar;50(4):468-78. Epub 2005 Nov 28. PMID: 16316670
2:Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects. Esbenshade TA, Krueger KM, Miller TR, Kang CH, Denny LI, Witte DG, Yao BB, Fox GB, Faghih R, Bennani YL, Williams M, Hancock AA.J Pharmacol Exp Ther. 2003 Jun;305(3):887-96. Epub 2003 Feb 20. PMID: 12606603 Free Article
3:Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization. Fox GB, Pan JB, Radek RJ, Lewis AM, Bitner RS, Esbenshade TA, Faghih R, Bennani YL, Williams M, Yao BB, Decker MW, Hancock AA.J Pharmacol Exp Ther. 2003 Jun;305(3):897-908. Epub 2003 Feb 20. PMID: 12606600 Free Article
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