For research use only. Not Intended for Therapeutic Use!
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Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola crenulata.
In vitro: Salidroside significantly reduces brain infarct size and cerebral edema. Salidroside could effectively decrease the levels of interleukin-6 (IL-6), interleukin- 1β (IL-1β), and tumor necrosis factor-α (TNF-α) in serum of the MCAO rats and supernatant of I/R-induced SH-SY5Y cells .
In vivo: Plasma, urine, bile, and feces samples were collected from
male rats after a single intragastric gavage of salidroside at a dose of 50 mg/kg. Results indicated that metabolic pathways of salidroside in male rats included hydroxylation, dehydrogenation, lucuronidation, and sulfate conjugation . SD rats were administrated with 50, 100, or 200 mg/kg salidroside for 28 days. BLM-triggered structure distortion, collagen overproduction, excessive inflammatory infiltration, and pro-inflammatory cytokine release, and oxidative stress damages in lung tissues were attenuated
by salidroside in a dose-dependent manner .
. Fei Han, et al. Metabolic profile of salidroside in rats using high-performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry. Anal Bioanal Chem, DOI 10.1007/s00216-015-9080-9
. Tong Chen, et al. Suppressing Receptor-Interacting Protein 140: a New Sight for Salidroside to Treat Cerebral Ischemia. Mol Neurobiol, DOI 10.1007/s12035-015-9521-7.
. Haiying Tang, et al. Salidroside protects against bleomycin-induced pulmonary fibrosis: activation of Nrf2-antioxidant signaling, and inhibition of NF-κB and TGF-β1/Smad-2/-3 pathways. Cell Stress and Chaperones , DOI 10.1007/s12192-015-0654-4