A-304121


CAS No. : 360551-71-9

A-304121,360551-71-9
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000188
Synonyms:A-304121;(2R)-2-amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]propan-1-one
Molecular Formula:C20H29N3O3
Molecular Weight:359.47
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Appearance:Solid powder
Purity: > 98%
Cat No:I000188
Cas No:360551-71-9
Product-Name:A-304121
IUPAC Name:(2R)-2-amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]propan-1-one
InChI:InChI=1S/C20H29N3O3/c1-15(21)20(25)23-12-10-22(11-13-23)9-2-14-26-18-7-5-17(6-8-18)19(24)16-3-4-16/h5-8,15-16H,2-4,9-14,21H2,1H3/t15-/m1/s1
InChIKey:KPXVCGPCRXEDLT-OAHLLOKOSA-N
SMILES:CC(C(=O)N1CCN(CC1)CCCOC2=CC=C(C=C2)C(=O)C3CC3)N
A-304121 is a histamine H(3) receptor.

1:Evidence for tolerance following repeated dosing in rats with ciproxifan, but not with A-304121. Pan JB, Yao BB, Miller TR, Kroeger PE, Bennani YL, Komater VA, Esbenshade TA, Hancock AA, Decker MW, Fox GB.Life Sci. 2006 Aug 29;79(14):1366-79. Epub 2006 Apr 26. PMID: 16730751
2:Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects. Esbenshade TA, Krueger KM, Miller TR, Kang CH, Denny LI, Witte DG, Yao BB, Fox GB, Faghih R, Bennani YL, Williams M, Hancock AA.J Pharmacol Exp Ther. 2003 Jun;305(3):887-96. Epub 2003 Feb 20. PMID: 12606603 Free Article
3:Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization. Fox GB, Pan JB, Radek RJ, Lewis AM, Bitner RS, Esbenshade TA, Faghih R, Bennani YL, Williams M, Yao BB, Decker MW, Hancock AA.J Pharmacol Exp Ther. 2003 Jun;305(3):897-908. Epub 2003 Feb 20. PMID: 12606600 Free Article
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