Trelagliptin succinate


CAS No. : 1029877-94-8

Trelagliptin succinate,1029877-94-8
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000181
Synonyms:2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile;butanedioic acid
Molecular Formula:C₂₂H₂₆FN₅O₆
Molecular Weight:475.47
Target:DPP-4
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Cat No:I000181
Cas No:1029877-94-8
Product-Name:Trelagliptin succinate
InChI:InChI=1S/C18H20FN5O2.C4H6O4/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20;5-3(6)1-2-4(7)8/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3;1-2H2,(H,5,6)(H,7,8)/t15-;/m1./s1
InChIKey:OGCNTTUPLQTBJI-XFULWGLBSA-N
SMILES:CN1C(=O)C=C(N(C1=O)CC2=C(C=CC(=C2)F)C#N)N3CCCC(C3)N.C(CC(=O)O)C(=O)O

Trelagliptin(SYR-472) is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D).
IC50 value:
Target: DPP4
Two Phase II clinical studies have been completed with Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus. Phase III clinical studies with trelagliptin in Japan to evaluate its safety and efficacy in a once-weekly oral treatment regimen. Currently, all available DPP-4 inhibitors are dosed once-daily. A once-weekly treatment, such as trelagliptin, would provide patients with a convenient treatment alternative and has the potential to improve treatment compliance.


[1]. Efficacy of SYR-472 in Subjects With Type 2 Diabetes Mellitus
[2]. Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus
[3]. Long-term Study of SYR-472
[4]. SYR-472 Open-label Study

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