A-1331852


CAS No. : 1430844-80-6

A-1331852,1430844-80-6
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000170
Synonyms:A-1331852; A 1331852; A1331852.;3-(1-(((3r,5r,7r)-adamantan-1-yl)methyl)-5-methyl-1H-pyrazol-4-yl)-6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)picolinic acid
Molecular Formula:C₃₈H₃₈N₆O₃S
Molecular Weight:658.81
Target:Bcl-xL
IC50:Ki: 6 nM for BCL-2 TR-FRET
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Appearance:Solid powder
Purity: > 98%
Cat No:I000170
Cas No:1430844-80-6
Product-Name:A-1331852
InChI:InChI=1S/C38H38N6O3S/c1-22-29(19-39-44(22)21-38-16-23-13-24(17-38)15-25(14-23)18-38)27-9-10-33(41-34(27)36(46)47)43-12-11-26-5-4-6-28(30(26)20-43)35(45)42-37-40-31-7-2-3-8-32(31)48-37/h2-10,19,23-25H,11-18,20-21H2,1H3,(H,46,47)(H,40,42,45)
InChIKey:QCQQONWEDCOTBV-UHFFFAOYSA-N
SMILES:CC1=C(C=NN1CC23CC4CC(C2)CC(C4)C3)C5=C(N=C(C=C5)N6CCC7=CC=CC(=C7C6)C(=O)NC8=NC9=CC=CC=C9S8)C(=O)O

A-1331852(cas 1430844-80-6) is a potent and BCL-XL-selective inhibitor. 

A-1331852 could selectively disrupt BCL-XL–BIM complexes and induce the apoptosis hallmarks in BCL-XL–dependent Molt-4 cells with median IC50 values in the low nanomolar range but did not affect MEF cells without BAK or BAX

1: Zhu Y, Doornebal EJ, Pirtskhalava T, Giorgadze N, Wentworth M, Fuhrmann-Stroissnigg H, Niedernhofer LJ, Robbins PD, Tchkonia T, Kirkland JL. New agents that target senescent cells: the flavone, fisetin, and the BCL-X(L) inhibitors, A1331852 and A1155463. Aging (Albany NY). 2017 Mar 8;9(3):955-963. doi: 10.18632/aging.101202. PubMed PMID: 28273655; PubMed Central PMCID: PMC5391241.


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