Tetrabenazine (+)-


CAS No. : 1026016-83-0

Tetrabenazine (+)-,1026016-83-0
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000169
Molecular Formula:C19H27NO3
Molecular Weight:317.42
Target:target: VMAT-2
Price:Get quote
We would like to match the lowest price on market if possible.

Your information is safe with us.

refresh
Cat No:I000169
Cas No:1026016-83-0
Product-Name:Tetrabenazine (+)-

Tetrabenazine ((+)-) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1.
target: VMAT-2
In vitro: Tetrabenazine ((+)-) inhibit the activity of the transporter but appear to interact differently with the protein. [2] Tetrabenazine ((+)-) inhibits reserpine binding to the transporter, suggesting that the sites may interact in an allosteric manner. [1]
In vivo: 0.9% saline (80%) and dimethylsulfoxide (DMSO) (20%). Tetrabenazine ((+)-) blocks dopamine (DA) storage and depletes striatal DA; Tetrabenazine ((+)-) was shown to induce tremulous jaw movements (TJMs) in rats and mice. The reference dose for administration is 2.0 mg/kg.[2]


[1]. Podurgiel SJ et al. The MAO-B inhibitor deprenyl reduces the oral tremor and the dopamine depletion induced by the VMAT-2 inhibitor tetrabenazine. Behav Brain Res. 2016 Feb 1;298(Pt B):188-91.
[2]. Peter D et al. Chimeric vesicular monoamine transporters identify structural domains that influence substrate affinity and sensitivity to tetrabenazine. J Biol Chem. 1996 Feb 9;271(6):2979-86.

Recommended Products
  • CAS No. :621-82-9
    Product Name:

    Cinnamic Acid

    Cat No: R060751 View details
  • CAS No. :181878-39-7
    Product Name:

    Ethyl 2-Methylbutyrate-D3

    Cat No: R060752 View details
  • CAS No. :5390-04-5
    Product Name:

    4-Pentyn-1-ol

    Cat No: R060754 View details
  • CAS No. :119-84-6
    Product Name:

    Hydrocoumarin

    Cat No: R060755 View details