(-)-Huperzine A

CAS No. : 102518-79-6

(-)-Huperzine A,102518-79-6
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000165
Molecular Formula:C15H18N2O
Molecular Weight:242.3
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Appearance:solid powder
Purity: > 98%
Cat No:I000165
Cas No:102518-79-6
Product-Name:(-)-Huperzine A

Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer/'s disease (AD).
IC50 value:
Target: AChE
Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. Huperzine A is a potential therapeutic agent for Alzheimer/'s disease.

1:Huperzine A inhibits immediate addictive behavior but not behavioral sensitization following repeated morphine administration in rats. Sun J, Tian L, Cui R, Li X.Exp Ther Med. 2017 Apr;13(4):1584-1591. doi: 10.3892/etm.2017.4097. Epub 2017 Feb 2. PMID: 28413513 Free PMC Article
2:Global transcriptome analysis of Huperzia serrata and identification of critical genes involved in the biosynthesis of huperzine A. Yang M, You W, Wu S, Fan Z, Xu B, Zhu M, Li X, Xiao Y.BMC Genomics. 2017 Mar 22;18(1):245. doi: 10.1186/s12864-017-3615-8. PMID: 28330463 Free PMC Article
3:Huperzine A: A promising anticonvulsant, disease modifying, and memory enhancing treatment option in Alzheimer/'s disease. Damar U, Gersner R, Johnstone JT, Schachter S, Rotenberg A.Med Hypotheses. 2017 Feb;99:57-62. doi: 10.1016/j.mehy.2016.12.006. Epub 2016 Dec 22. PMID: 28110700
4:Acetylcholinesterase-independent protective effects of huperzine A against iron overload-induced oxidative damage and aberrant iron metabolism signaling in rat cortical neurons. Tao LX, Huang XT, Chen YT, Tang XC, Zhang HY.Acta Pharmacol Sin. 2016 Nov;37(11):1391-1400. doi: 10.1038/aps.2016.78. Epub 2016 Aug 8. PMID: 27498774 Free PMC Article
5:Huperzine A Provides Robust and Sustained Protection against Induced Seizures in Scn1a Mutant Mice. Wong JC, Dutton SB, Collins SD, Schachter S, Escayg A.Front Pharmacol. 2016 Oct 17;7:357. eCollection 2016. PMID: 27799911 Free PMC Article
6:Evaluation of the in vitro and in vivo metabolic pathway and cytochrome P450 inhibition/induction profile of Huperzine A. Lin PP, Li XN, Yuan F, Chen WL, Yang MJ, Xu HR.Biochem Biophys Res Commun. 2016 Nov 11;480(2):248-253. doi: 10.1016/j.bbrc.2016.10.039. Epub 2016 Oct 15. PMID: 27751854
7:Chemical Transformation of an Intermediate in the Synthesis of Huperzine A, Leading to a Diverse Array of Molecules. Yokoshima S, Ishikawa M, Beniyama Y, Fukuyama T.Chem Pharm Bull (Tokyo). 2016;64(10):1528-1531. PMID: 27725508 Free Article
8:Huperzine A for treatment of cognitive impairment in major depressive disorder: a systematic review of randomized controlled trials. Zheng W, Xiang YQ, Ungvari GS, Chiu FK, H Ng C, Wang Y, Xiang YT.Shanghai Arch Psychiatry. 2016 Apr 25;28(2):64-71. doi: 10.11919/j.issn.1002-0829.216003. Review. PMID: 27605862 Free PMC Article
9:Effect of Huperzine A on Aβ-induced p65 of astrocyte in vitro. Xie L, Jiang C, Wang Z, Yi X, Gong Y, Chen Y, Fu Y.Biosci Biotechnol Biochem. 2016 Dec;80(12):2334-2337. Epub 2016 Aug 24. PMID: 27554967
10:Huperzine A protects sepsis associated encephalopathy by promoting the deficient cholinergic nervous function. Zhu SZ, Huang WP, Huang LQ, Han YL, Han QP, Zhu GF, Wen MY, Deng YY, Zeng HK.Neurosci Lett. 2016 Sep 19;631:70-8. doi: 10.1016/j.neulet.2016.07.009. Epub 2016 Jul 9. PMID: 27400829
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