A-123189


CAS No. : 255713-53-2

A-123189,255713-53-2
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000161
Synonyms:A-123189;3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-5-(3-methylphenyl)-1H-thieno[3,2-e]pyrimidine-2,4-dione
Molecular Formula:C26H28N4O3S
Molecular Weight:476.595
Target:alpha1D antagonist
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Appearance:Solid powder
Purity: > 98%
Cat No:I000161
Cas No:255713-53-2
Product-Name:A-123189
InChI:InChI=1S/C26H28N4O3S/c1-18-6-5-7-19(16-18)20-17-34-24-23(20)25(31)30(26(32)27-24)15-12-28-10-13-29(14-11-28)21-8-3-4-9-22(21)33-2/h3-9,16-17H,10-15H2,1-2H3,(H,27,32)
InChIKey:PANBMHHKBRMYAL-UHFFFAOYSA-N
SMILES:O=C1N(CCN2CCN(C3=CC=CC=C3OC)CC2)C(C(C(C4=CC=CC(C)=C4)=CS5)=C5N1)=O
A-123189(cas 255713-53-2) is a novel, selective and potent alpha1D antagonist.

1. Bioorg Med Chem Lett. 2001 May 7;11(9):1119-21.

Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien.

Carroll WA(1), Sippy KB, Esbenshade TA, Buckner SA, Hancock AA, Meyer MD.

Author information: 
(1)Abbott Laboratories, Neurological and Urological Diseases Research, Abbott
Park, IL 60064-6101, USA. william.a.carroll@abbott.com

The synthesis and in vitro characterization of A-119637 and A-123189, two novel, 
selective and potent alpha1D antagonists, are described.


PMID: 11354357  [Indexed for MEDLINE]


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