ARN2966


CAS No. : 102212-26-0

ARN2966,102212-26-0
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000154
Synonyms:2-((pyridin-2-ylmethyl)amino)phenol
Molecular Formula:C12H12N2O
Molecular Weight:200.2
Target:Amyloid β
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Cat No:I000154
Cas No:102212-26-0
Product-Name:ARN2966
InChIKey:GXJRVWZNMZGWAQ-UHFFFAOYSA-N

ARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ.
IC50 value:
Target: Aβ
This potent post-transcriptional modulation of APP expression differs from other mechanisms such as inhibition of secretases. Secretase inhibitors have been pursued as disease modifying strategies by a number of pharmaceutical firms but they have encountered numerous setbacks during clinical development. ARN2966 is non toxic, orally absorbable, blood-brain-barrier penetrable, and effective in vitro and in vivo.


[1]. http://arianeurosciences.com/science.html

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