CARM1-IN-1


CAS No. : 1020399-49-8

CARM1-IN-1,1020399-49-8
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000146
Synonyms:Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1 Inhibitor
Molecular Formula:C26H21Br2NO3
Molecular Weight:555.3
Target:CRAM1
IC50:8.6 uM
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Assay:≥95%
Appearance:A crystalline solid
Cat No:I000146
Cas No:1020399-49-8
Product-Name:CARM1-IN-1
InChIKey:KNMFTTWVELIVCC-CLVAPQHMSA-N

CARM1-IN-1 is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM). 

in vitro: CARM1-IN-1(Cmp 7g) displayed high and selective CARM1 inhibition, with lower or no activity against a panel of different PRMTs or HKMTs. In human LNCaP cells, 7g showed a significant dose-dependent reduction of the PSA promoter activity.

[1]. Cheng D, et al. Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem. 2011 Jul 14;54(13):4928-32.
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