LPA2 antagonist 1


CAS No. : 1017606-66-4

LPA2 antagonist 1,1017606-66-4
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000131
Synonyms:(S)-N-(1-(4-((3,4-dichlorophenyl)sulfonyl)piperazin-1-yl)propan-2-yl)-7-methylthieno[3,2-d]pyrimidin-4-amine
Molecular Formula:C20H23Cl2N5O2S2
Molecular Weight:500.457
Target:LPL Receptor
IC50:> 30 uM [1]
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Appearance:Solid powder
Purity: > 98%
Cat No:I000131
Cas No:1017606-66-4
Product-Name:LPA2 antagonist 1
IUPAC Name:N-[(2S)-1-[4-(3,4-dichlorophenyl)sulfonylpiperazin-1-yl]propan-2-yl]-7-methylthieno[3,2-d]pyrimidin-4-amine
InChI:InChI=1S/C20H23Cl2N5O2S2/c1-13-11-30-19-18(13)23-12-24-20(19)25-14(2)10-26-5-7-27(8-6-26)31(28,29)15-3-4-16(21)17(22)9-15/h3-4,9,11-12,14H,5-8,10H2,1-2H3,(H,23,24,25)/t14-/m0/s1
InChIKey:BPRNMVDTWIHULJ-AWEZNQCLSA-N
SMILES:CC1=CSC2=C1N=CN=C2NC(C)CN3CCN(CC3)S(=O)(=O)C4=CC(=C(C=C4)Cl)Cl

LPA2 antagonist1 is a selective inhibitor of LPA2 activity in with IC50 17 nM in vitro for inhibition of LPA(2) mediated Erk activation and proliferation of HCT-116 cells.
IC50 value: > 30 uM [1]
Target: LPA2


[1]. Beck HP, et al. Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1037-41.
[2]. Kozian DH, et al. Selective non-lipid modulator of LPA5 activity in human platelets. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5239-43.

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