9-Hydroxyellipticine Hydrochloride


CAS No. : 52238-35-4

9-Hydroxyellipticine Hydrochloride,52238-35-4
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000124
Molecular Formula:C17H15ClN2O
Molecular Weight:298.77
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Appearance:Solid powder
Purity: > 98%
Cat No:I000124
Cas No:52238-35-4
Product-Name:9-Hydroxyellipticine Hydrochloride
IUPAC Name:5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol;hydrochloride
InChI:InChI=1S/C17H14N2O.ClH/c1-9-14-8-18-6-5-12(14)10(2)17-16(9)13-7-11(20)3-4-15(13)19-17;/h3-8,19-20H,1-2H3;1H
InChIKey:DLDKVFOKLGPVBT-UHFFFAOYSA-N
SMILES:CC1=C2C(=C(C3=C1C=CN=C3)C)C4=C(N2)C=CC(=C4)O.Cl

9-Hydroxyellipticine Hydrochloride(cas 52238-35-4), also known as IGIG 929 and LS133324, is a potent cytotoxic and antitumor agent. Structurally, 9-hydroxyellipticine is a 9-hydroxy derivative of ellipticine. 


1: Saeki K, Obi I, Ogiku N, Shigekawa M, Imagawa T, Matsumoto T. Cardioprotective effects of 9-hydroxyellipticine on ischemia and reperfusion in isolated rat heart. Jpn J Pharmacol. 2002 May;89(1):21-8. PubMed PMID: 12083739.
2: Sugikawa E, Tsunoda S, Nakanishi N, Ohashi M. 9-Hydroxyellipticine alters the conformation and DNA binding characteristics of mutated p53 protein. Anticancer Res. 2001 Jul-Aug;21(4A):2671-5. PubMed PMID: 11724337.
3: Ohashi M, Sugikawa E, Nakanishi N. Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism. Jpn J Cancer Res. 1995 Sep;86(9):819-27. PubMed PMID: 7591958.
4: Braham Y, Meunier G, Meunier B. [Demonstration of an oxidative biotransformation of 9-methoxyellipticine. Comparison with the case of 9-hydroxyellipticine]. C R Acad Sci III. 1987;304(11):301-6. French. PubMed PMID: 3103875.
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