Tenovin-3


CAS No. : 1011301-27-1

Tenovin-3,1011301-27-1
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000115
Synonyms:Tenovin 3
Molecular Formula:C18H21N3OS
Molecular Weight:327.4
Target:p53
Price:Get quote
We would like to match the lowest price on market if possible.

Your information is safe with us.

refresh
Appearance:Solid powder
Purity: > 98%
Cat No:I000115
Cas No:1011301-27-1
Product-Name:Tenovin-3
InChI:InChI=1S/C18H21N3OS/c1-18(2,3)13-6-4-12(5-7-13)16(22)21-17(23)20-15-10-8-14(19)9-11-15/h4-11H,19H2,1-3H3,(H2,20,21,22,23)
InChIKey:NLAXTZPUTNGRDU-UHFFFAOYSA-N
SMILES:CC(C)(C)C1=CC=C(C(NC(NC2=CC=C(N)C=C2)=S)=O)C=C1

Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM. 

in vitro: Tenovins inhibit the activities of human SirT1 and SirT2, two members of the NAD+-dependent class III histone deacetylases that also belong to the sirtuin family.[1]

[1]. Lain S, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63.
Related Products
  • CAS No. :1197996-80-7
    Product Name:

    Curaxin (CBL0137) (discontinued)

    Cat No: I006313 View details
  • CAS No. :1036069-26-7
    Product Name:

    RETRA hydrochloride

    Cat No: I011715 View details
  • CAS No. :1352066-68-2
    Product Name:

    AMG-232

    Cat No: I001358 View details
  • CAS No. :881202-45-5
    Product Name:

    JNJ-26854165

    Cat No: I005297 View details