ML346


CAS No. : 100872-83-1

ML346,100872-83-1
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000100
Molecular Formula:C14H12N2O4
Molecular Weight:272.26
Target:Hsp70
IC50:4600 nM (EC50)
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Appearance:Solid powder
Purity: > 98%
Cat No:I000100
Cas No:100872-83-1
Product-Name:ML346
InChI:InChI=1S/C14H12N2O4/c1-20-10-7-5-9(6-8-10)3-2-4-11-12(17)15-14(19)16-13(11)18/h2-8H,1H3,(H2,15,16,17,18,19)/b3-2+
InChIKey:IXYLVJHFJKDHRM-NSCUHMNNSA-N
SMILES:O=C(NC(NC/1=O)=O)C1=CC=CC2=CC=C(OC)C=C2

ML346 is a novel activator of Hsp70 with EC50 of 4600 nM in HeLa cell toxicity assay.
IC50 value: 4600 nM (EC50)
Target: Hsp70
in vitro: ML346 has good chemical stability, significantly high water solubility, is not reactive with excess glutathione, and is cell permeable. The probe ML346 will help elucidate roles for activation of Hsp70 and HSF-1 in the prevention and progression of cancers, cellular aging, and metabolic and neurodegenerative disorders. ML346 is a novel modulator of proteostasis for protein conformational diseases.
in vivo: ML346 activates transcription of the Hsp70 promoter and suppresses aggregation of poly-glutamines in a C. elegans model, suggesting the probe has efficacy in modifying protein aggregation and associated toxicity. ML346 induces HSF-1-dependent chaperone expression and restores protein folding in conformational disease models.


[1]. Calamini B, et al. ML346: A Novel Modulator of Proteostasis for Protein Conformational Diseases.Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2012 Dec 17.

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