Piceatannol


CAS No. : 10083-24-6

Piceatannol,10083-24-6
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000099
Synonyms:4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol
Molecular Formula:C₁₄H₁₂O₄
Molecular Weight:244.24
Target:IκB/IKK
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Appearance: Powder
Purity: 98.5%
Cat No:I000099
Cas No:10083-24-6
Product-Name:Piceatannol
MDL No:MFCD00221715
InChI:InChI=1S/C14H12O4/c15-11-5-10(6-12(16)8-11)2-1-9-3-4-13(17)14(18)7-9/h1-8,15-18H/b2-1+
InChIKey:CDRPUGZCRXZLFL-OWOJBTEDSA-N
SMILES:C1=CC(=C(C=C1C=CC2=CC(=CC(=C2)O)O)O)O

Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.
In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppressed in lymphocyte and epithelial cells. Piceatannol also inhibited NF-κB activated by H2O2, PMA, LPS, okadaic acid, and ceramide. [1]


[1]. Kazuhiro Ashikawa et al. Piceatannol Inhibits TNF-Induced NF-κB Activation and NF-κB-Mediated Gene Expression Through Suppression of IκBα Kinase and p65 Phosphorylation. J Immunol, 2002 Dec 1, 169(11):6490-7.
[2]. Wen-Pin Chen et al. Piceatannol, a derivative of resveratrol, moderately slows INa inactivation and exerts antiarrhythmic action in ischaemia-reperfused rat hearts. Br J Pharmacol.2009 Jun, 157(3), 381-391.

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