CAS No. : 13309-08-5

Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000057
Molecular Formula:C13H10N2O
Molecular Weight:210.236
Target:PFKFB3 inhibitor
Price:Get quote
We would like to match the lowest price on market if possible.

Your information is safe with us.

Appearance:Solid powder
Purity: > 98%
Cat No:I000057
Cas No:13309-08-5
IUPAC Name:(E)-3-pyridin-3-yl-1-pyridin-4-ylprop-2-en-1-one
3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor. 3PO reduces glycolytic flux and suppresses glucose uptake. 3PO may be useful agents in combination with other drugs that inhibit cancer cell proliferation. PFKFB3 inhibitors suppress glucose uptake, which in turn causes an increase in autophagy. The addition of selective inhibitors of autophagy to 3PO and its more potent derivatives may prove useful as rational combinations for the treatment of cancer.

1:Impact of the cellular prion protein on amyloid-β and 3PO-tau processing. Schmitz M, Wulf K, Signore SC, Schulz-Schaeffer WJ, Kermer P, Bähr M, Wouters FS, Zafar S, Zerr I.J Alzheimers Dis. 2014;38(3):551-65. doi: 10.3233/JAD-130566. PMID: 24028865
2:3PO, a novel nonviral gene delivery system using engineered Ad5 penton proteins. Medina-Kauwe LK, Kasahara N, Kedes L.Gene Ther. 2001 May;8(10):795-803. PMID: 11420644 Free Article
3:Measurement of the lifetime of the 1s2p 3Po state in Be Scholl TJ, Rosner SD, Holt RA.Phys Rev A. 1996 Apr;53(4):2130-2134. No abstract available. PMID: 9913118
4:Electron affinities of 1s22s2p 3Po and 1s22p2 3P of beryllium. Hsu JJ, Chung KT.Phys Rev A. 1995 Aug;52(2):R898-R901. No abstract available. PMID: 9912431
5:Doubly excited 3Po resonance states of He below the N=2 and N=3 He+ thresholds. Ho YK.Phys Rev A. 1993 Nov;48(5):3598-3605. No abstract available. PMID: 9910025
6:CEO expectation: the Star Wars materiel manager of the 1990s, or C-3PO as role model. Zenty TF, Olson MR.Hosp Mater Manage Q. 1993 May;14(4):15-20. PMID: 10125274
7:Multichannel photoionization of metastable He(2 (3)Se): A complete study of the 3Po resonances between the N=2 and 3 thresholds. Sánchez I I, Martin F.Phys Rev A. 1993 Mar;47(3):1878-1886. No abstract available. PMID: 9909142
8:1,3Po resonance states in positronium ions. Ho YK, Bhatia AK.Phys Rev A. 1991 Sep 1;44(5):2890-2894. No abstract available. PMID: 9906287
Recommended Products
  • CAS No. :
    Product Name:


    Cat No: M013715 View details
  • CAS No. :
    Product Name:

    methyl 5-(2-hydroxyphenyl)-1-(4-methoxyphenyl)imidazole-4-carboxylate

    Cat No: M014318 View details
  • CAS No. :5399-63-3
    Product Name:

    p-Sulfobenzoic acid monopotassium salt

    Cat No: R070912 View details
  • CAS No. :5007-67-0
    Product Name:

    3.3/'.4.4/'-Tetra aminobenzophenone

    Cat No: R070917 View details