Pentoxifylline


CAS No. : 6493-05-6

Pentoxifylline,6493-05-6
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000055
Synonyms:NSC 637086;Oxpentifylline
Molecular Formula:C13H18N4O3
Molecular Weight:278.3
Target:PDE
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Appearance:Solid powder
Purity: > 98%
Cat No:I000055
Cas No:6493-05-6
Product-Name:Pentoxifylline
InChI:InChI=1S/C13H18N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8H,4-7H2,1-3H3
InChIKey:BYPFEZZEUUWMEJ-UHFFFAOYSA-N
SMILES:CC(CCCCN1C(N(C)C(N=CN2C)=C2C1=O)=O)=O

Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor.
Target: PDE
Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity. In addition, pentoxifylline improves red blood cell deformability, reduces blood viscosity and decreases the potential for platelet aggregation and thrombus formation. Pentoxifylline is also an antagonist at adenosine 2 receptors [1].
Pentoxifylline is generally well tolerated. Based on the totality of the available evidence, it is possible that pentoxifylline could have a place in the treatment of IC as a means of improving walking distance and as a complimentary treatment assuming all other essential measures such as lifestyle change, exercise and treatment for secondary prevention have been taken into account [2]. Pentoxifylline reduce AST and ALT levels and may improve liver histological scores in patients with NALFD/NASH, but did not appear to affect cytokines. Large, prospective, and well-designed randomized, controlled studies are needed to address this issue [3].


1:Effect of Pentoxifylline in Ameliorating Myocardial Injury in Patients With Myocardial Infarction Undergoing Thrombolytic Therapy: A Pilot Randomized Clinical Trial. Namdar H, Zohori R, Aslanabadi N, Entezari-Maleki T.J Clin Pharmacol. 2017 May 17. doi: 10.1002/jcph.926. [Epub ahead of print] PMID: 28513852
2:Oral Pentoxifylline Associated with Pentavalent Antimony: A Randomized Trial for Cutaneous Leishmaniasis. Brito G, Dourado M, Guimarães LH, Meireles E, Schriefer A, de Carvalho EM, Machado PRL.Am J Trop Med Hyg. 2017 May;96(5):1155-1159. doi: 10.4269/ajtmh.16-0435. PMID: 28500815
3:Administration of pentoxifylline to improve anemia of hemodialysis patients. Shahbazian H, Ghorbani A, Zafar-Mohtashami A, Balali A, AleAli A, Lashkarara GR.J Renal Inj Prev. 2016 Nov 26;6(1):61-64. doi: 10.15171/jrip.2017.11. eCollection 2017. PMID: 28487874 Free PMC Article
4:Repurposing Pentoxifylline for the Treatment of Fibrosis: An Overview. Wen WX, Lee SY, Siang R, Koh RY.Adv Ther. 2017 May 8. doi: 10.1007/s12325-017-0547-2. [Epub ahead of print] Review. PMID: 28484954
5:Pentoxifylline and prevention of contrast-induced nephropathy: Is it efficient in patients with myocardial infarction undergoing coronary angioplasty? Eshraghi A, Naranji-Sani R, Pourzand H, Vojdanparast M, Morovatfar N, Ramezani J, Khamene-Bagheri R, Nezafati P.ARYA Atheroscler. 2016 Sep;12(5):238-242. PMID: 28458699 Free PMC Article
6:Pentoxifylline increase sperm motility in devitrified spermatozoa from asthenozoospermic patient without damage chromatin and DNA integrity. Nabi A, Khalili MA, Fesahat F, Talebi A, Ghasemi-Esmailabad S.Cryobiology. 2017 Apr 25. pii: S0011-2240(16)30371-6. doi: 10.1016/j.cryobiol.2017.04.008. [Epub ahead of print] PMID: 28455156
7:Pentoxifylline plus ACEIs/ARBs for proteinuria and kidney function in chronic kidney disease: a meta-analysis. Liu D, Wang LN, Li HX, Huang P, Qu LB, Chen FY.J Int Med Res. 2017 Apr;45(2):383-398. doi: 10.1177/0300060516663094. Epub 2017 Jan 1. PMID: 28415944
8:The effects of pentoxifylline adminstration on fracture healing in a postmenopausal osteoporotic rat model. Vashghani Farahani MM, Ahadi R, Abdollahifar M, Bayat M.Lab Anim Res. 2017 Mar;33(1):15-23. doi: 10.5625/lar.2017.33.1.15. Epub 2017 Mar 27. PMID: 28400835 Free PMC Article
9:Alleviation of Oxidative Damage and Involvement of Nrf2-ARE Pathway in Mesodopaminergic System and Hippocampus of Status Epilepticus Rats Pretreated by Intranasal Pentoxifylline. Kang Y, Yan W, Fang H, Zhang G, Du Y, Wang L, Cui H, Shi G.Oxid Med Cell Longev. 2017;2017:7908072. doi: 10.1155/2017/7908072. Epub 2017 Mar 12. PMID: 28386312 Free PMC Article
10:Pentoxifylline Regulates Plasminogen Activator Inhibitor-1 Expression and Protein Kinase A Phosphorylation in Radiation-Induced Lung Fibrosis. Lee JG, Shim S, Kim MJ, Myung JK, Jang WS, Bae CH, Lee SJ, Kim KM, Jin YW, Lee SS, Park S.Biomed Res Int. 2017;2017:1279280. doi: 10.1155/2017/1279280. Epub 2017 Feb 27. PMID: 28337441 Free PMC Article
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