10074-G5


CAS No. : 413611-93-5

10074-G5,413611-93-5
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000047
Synonyms:10074-G5; 10074G5;;Biphenyl-2-yl-(7-nitrobenzo[1,2,5]oxadiazol-4-yl)amine
Molecular Formula:C18H12N4O3
Molecular Weight:332.3
Target:c-Myc
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Appearance:Solid powder
Purity: > 98%
Cat No:I000047
Cas No:413611-93-5
Product-Name:10074-G5
InChI:InChI=1S/C18H14N4O3/c23-22(24)18-11-10-16(17-12-19-25-21(17)18)20-15-9-5-4-8-14(15)13-6-2-1-3-7-13/h1-12,19-20H
InChIKey:KMJPYSQOCBYMCF-UHFFFAOYSA-N
SMILES:O=[N+](C(C1=NON=C12)=CC=C2NC3=CC=CC=C3C4=CC=CC=C4)[O-]
10074-G5(cas 413611-93-5) is a c-Myc/Max interaction inhibitor. 10074-G5, similarly to 10058-F4 (#F3680), specifically inhibits this interaction by binding to c-Myc, thus preventing C-Myc specific DNA binding and target genes regulation.
1: Yap JL, Wang H, Hu A, Chauhan J, Jung KY, Gharavi RB, Prochownik EV, Fletcher S. Pharmacophore identification of c-Myc inhibitor 10074-G5. Bioorg Med Chem Lett. 2013 Jan 1;23(1):370-4. doi: 10.1016/j.bmcl.2012.10.013. Epub 2012 Oct 17. PubMed PMID: 23177256; PubMed Central PMCID: PMC3525812.
2: Wang H, Chauhan J, Hu A, Pendleton K, Yap JL, Sabato PE, Jones JW, Perri M, Yu J, Cione E, Kane MA, Fletcher S, Prochownik EV. Disruption of Myc-Max heterodimerization with improved cell-penetrating analogs of the small molecule 10074-G5. Oncotarget. 2013 Jun;4(6):936-47. PubMed PMID: 23801058; PubMed Central PMCID: PMC3757250.
3: Clausen DM, Guo J, Parise RA, Beumer JH, Egorin MJ, Lazo JS, Prochownik EV, Eiseman JL. In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization. J Pharmacol Exp Ther. 2010 Dec;335(3):715-27. doi: 10.1124/jpet.110.170555. Epub 2010 Aug 26. PubMed PMID: 20801893; PubMed Central PMCID: PMC2993546.
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