Folinic acid

CAS No. : 58-05-9

Folinic acid,58-05-9
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000020
Molecular Formula:C20H23N7O7
Molecular Weight:473.44
Price:Get quote
We would like to match the lowest price on market if possible.

Your information is safe with us.

Cat No:I000020
Cas No:58-05-9
Product-Name:Folinic acid

Folinic acid is an adjuvant used in cancer chemotherapy involving the drug methotrexate.
Target: Antifolate
Folinic acid is a 5-formyl derivative of tetrahydrofolic acid. It is readily converted to other reduced folic acid derivatives (e.g., tetrahydrofolate), and, thus, has vitamin activity that is equivalent to that of folic acid. Since it does not require the action of dihydrofolate reductase for its conversion, its function as a vitamin is unaffected by inhibition of this enzyme by drugs such as methotrexate. In 1980s, however, folinic acid was found to reactivate the dihydrofolate reductase itself even when methotrexate exists. Although the mechanism is not very clear, the polyglutamylation of methotrexate and dihydrofolate in malignant cells is considered to play an important role in the selective reactivation of dihydrofolate reductase by folinic acid in normal cells [1]. Folinic acid is generally administered along with MTX as a rescue agent to decrease MTX-induced toxicity. However, information regarding the inhibitory effect of folinic acid against cytogenetic damage caused by MTX is limited. This study was conducted to assess the cytogenetic effect of MTX and its inhibition by folinic acid (FA) using the micronucleus and chromosomal aberration assays concurrently [2].

[1]. Goldman, I.D. and L.H. Matherly, Biochemical factors in the selectivity of leucovorin rescue: selective inhibition of leucovorin reactivation of dihydrofolate reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate polyglutamates. NCI Monogr, 1987(5): p. 17-26.
[2]. Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8.

Related Products
  • CAS No. :1492-18-8
    Product Name:

    Folinic acid Calcium

    Cat No: I001836 View details
  • CAS No. :137281-23-3
    Product Name:


    Cat No: I001434 View details