Favipiravir


CAS No. : 259793-96-9

Favipiravir,259793-96-9
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000017
Synonyms:Favipiravir
Molecular Formula:C5H4FN3O2
Molecular Weight:157.1
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Inventory Status:In Stock
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Appearance:Solid powder
Purity: > 98%
Cat No:I000017
Cas No:259793-96-9
Product-Name:Favipiravir
Related Cas:I000017
MDL No:MFCD12032148
InChI:InChI=1S/C5H4FN3O2/c6-2-1-8-5(11)3(9-2)4(7)10/h1H,(H2,7,10)(H,8,11)
InChIKey:ZCGNOVWYSGBHAU-UHFFFAOYSA-N
SMILES:O=C(C1=NC(F)=CN=C1O)N
Favipiravir(cas 259793-96-9), also known as T-705 or Avigan, is an antiviral drug that selectively inhibits the RNA-dependent RNA polymerase of influenza virus. Favipiravir is phosphoribosylated by cellular enzymes to its active form, favipiravir-ribofuranosyl-5/'-triphosphate (RTP).  Favipiravir is active against a broad range of influenza viruses, including A(H1N1)pdm09, A(H5N1) and the recently emerged A(H7N9) avian virus. Favipiravir also inhibits influenza strains resistant to current antiviral drugs, and shows a synergistic effect in combination with oseltamivir, thereby expanding influenza treatment options.
1: Rocha-Pereira J, Jochmans D, Dallmeier K, Leyssen P, Nascimento MS, Neyts J. Favipiravir (T-705) inhibits in vitro norovirus replication. Biochem Biophys Res Commun. 2012 Aug 10;424(4):777-80. doi: 10.1016/j.bbrc.2012.07.034. Epub 2012 Jul 15. PubMed PMID: 22809499.
2: Mendenhall M, Russell A, Smee DF, Hall JO, Skirpstunas R, Furuta Y, Gowen BB. Effective oral favipiravir (T-705) therapy initiated after the onset of clinical disease in a model of arenavirus hemorrhagic Fever. PLoS Negl Trop Dis. 2011 Oct;5(10):e1342. doi: 10.1371/journal.pntd.0001342. Epub 2011 Oct 11. PubMed PMID: 22022624; PubMed Central PMCID: PMC3191123.
3: Mendenhall M, Russell A, Juelich T, Messina EL, Smee DF, Freiberg AN, Holbrook MR, Furuta Y, de la Torre JC, Nunberg JH, Gowen BB. T-705 (favipiravir) inhibition of arenavirus replication in cell culture. Antimicrob Agents Chemother. 2011 Feb;55(2):782-7. doi: 10.1128/AAC.01219-10. Epub 2010 Nov 29. PubMed PMID: 21115797; PubMed Central PMCID: PMC3028760.
4: Kiso M, Takahashi K, Sakai-Tagawa Y, Shinya K, Sakabe S, Le QM, Ozawa M, Furuta Y, Kawaoka Y. T-705 (favipiravir) activity against lethal H5N1 influenza A viruses. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):882-7. doi: 10.1073/pnas.0909603107. Epub 2009 Dec 22. PubMed PMID: 20080770; PubMed Central PMCID: PMC2818889.
5: Smee DF, Hurst BL, Egawa H, Takahashi K, Kadota T, Furuta Y. Intracellular metabolism of favipiravir (T-705) in uninfected and influenza A (H5N1) virus-infected cells. J Antimicrob Chemother. 2009 Oct;64(4):741-6. doi: 10.1093/jac/dkp274. Epub 2009 Jul 29. PubMed PMID: 19643775; PubMed Central PMCID: PMC2740635.
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