CAS No. : 472-26-4

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For research use only. Not Intended for Therapeutic Use!
Cat No:I000011
Molecular Formula:C24H34O5
Molecular Weight:402.52
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Purity      ≥ 98.0%
Cat No:I000011
Cas No:472-26-4

Telocinobufagin(cas 472-26-4) is one of anti-hepatoma constituent in Venenum Bufonis.

in vitro: Telocinobufagin markedly enhances natural killer cell and peritoneal macrophage activation. Telocinobufagin increases the percentage of CD4, CD8 positive cells within a population of splenocytes. 

1:[Mechanism of colon cancer cell apoptosis induced by telocinobufagin: role of oxidative stress and apoptosis pathway]. Liang ST, Li Y, Li XW, Wang JJ, Tan FX, Han QR, Li L, Yao XQ, Sun XG.Nan Fang Yi Ke Da Xue Xue Bao. 2016 Jun 20;36(7):921-6. Chinese. PMID: 27435769
2:Telocinobufagin enhances the Th1 immune response and protects against Salmonella typhimurium infection. Wu SC, Fu BD, Shen HQ, Yi PF, Zhang LY, Lv S, Guo X, Xia F, Wu YL, Wei XB.Int Immunopharmacol. 2015 Apr;25(2):353-62. doi: 10.1016/j.intimp.2015.02.005. Epub 2015 Feb 14. PMID: 25687199
3:The effects of telocinobufagin isolated from Chan Su on the activation and cytokine secretion of immunocytes in vitro. Cao Y, Song Y, An N, Zeng S, Wang D, Yu L, Zhu T, Zhang T, Cui J, Zhou C, Deng X.Fundam Clin Pharmacol. 2009 Aug;23(4):457-64. doi: 10.1111/j.1472-8206.2009.00696.x. PMID: 19709323
4:Antimicrobial activity of the bufadienolides marinobufagin and telocinobufagin isolated as major components from skin secretion of the toad Bufo rubescens. Cunha Filho GA, Schwartz CA, Resck IS, Murta MM, Lemos SS, Castro MS, Kyaw C, Pires OR Jr, Leite JR, Bloch C Jr, Schwartz EF.Toxicon. 2005 May;45(6):777-82. PMID: 15804527
5:A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure. Komiyama Y, Dong XH, Nishimura N, Masaki H, Yoshika M, Masuda M, Takahashi H.Clin Biochem. 2005 Jan;38(1):36-45. PMID: 15607315
6:Bufadienolides. 27. Synthesis of telocinobufagin. Pettit GR, Kamano Y.J Org Chem. 1974 Aug 23;39(17):2632-4. No abstract available. PMID: 4412260
7:Comparison of cardiac action of bufalin, cinobufotalin, and telocinobufagin with cinobufagin. CHEN KK, ANDERSON RC, HENDERSON FG.Proc Soc Exp Biol Med. 1951 Feb;76(2):372-4. No abstract available. PMID: 14827929
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