CAS No. : 163252-36-6

Clevudine ,163252-36-6
Product Details
Cat No:A001224
Molecular Formula:C10H13FN2O5
Molecular Weight:260.22
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Appearance:Solid powder
Cat No:A001224
Cas No:163252-36-6
Clevudine, also known as L-FMAU, is an antiviral used in the treatment of Hepatitis B. Clevudine is differentiated from other oral agents by an unusual activation pathway to the biochemically active triphosphate, a mechanism of action of clevudine triphosphate that inhibits multiple steps of the hepatitis B virus (HBV) intracellular life cycle, a long half-life, and significant reduction of covalently closed circular DNA (cccDNA) in animal models.

1:Management of Clevudine-Resistant Chronic Hepatitis B: A Multicenter Cohort Study. Cho EY, Yim HJ, Jung YK, Suh SJ, Seo YS, Kim JH, Kim HS, Lee SH, Ahn SH, Lee JI, Jeong SH, Kim JW, Lee JW, Kim IH, Kim HS, Park SJ, Lee JM, Hwang SG; Antiviral Resistance Study Group..Gut Liver. 2017 Jan 15;11(1):129-135. doi: 10.5009/gnl15597. PMID: 27538443 Free PMC Article
2:A randomized, open-label study comparing low-dose clevudine plus adefovir combination therapy with clevudine monotherapy in naïve chronic hepatitis B patients. Tak WY, Yang JM, Kim BI, Baik SK, Cheon GJ, Byun KS, Kim DY, Yoo BC.Hepatol Int. 2014 May 25;8(3):375-81. doi: 10.1007/s12072-014-9537-5. eCollection 2014 Jul. PMID: 25101150 Free PMC Article
3:Virological Response and Muscular Adverse Events during Long-Term Clevudine Therapy in Chronic Hepatitis B Patients. Kim BK, Ko SY, Kwon SY, Park E, Kim JH, Choe WH, Lee CH.Hepat Mon. 2013 Apr 1;13(4):e6056. doi: 10.5812/hepatmon.6056. Print 2013 Apr. PMID: 23805155 Free PMC Article
4:Noncompetitive inhibition of hepatitis B virus reverse transcriptase protein priming and DNA synthesis by the nucleoside analog clevudine. Jones SA, Murakami E, Delaney W, Furman P, Hu J.Antimicrob Agents Chemother. 2013 Sep;57(9):4181-9. doi: 10.1128/AAC.00599-13. Epub 2013 Jun 17. Erratum in: Antimicrob Agents Chemother. 2013 Nov;57(11):5788. PMID: 23774432 Free PMC Article
5:[Antiviral effect of entecavir switching therapy in chronic hepatitis B patients with clevudine-associated myopathy]. Tak WY.Korean J Gastroenterol. 2013 Jan 25;61(1):1-2. Korean. No abstract available. PMID: 23472271 Free Article
6:A comparison of clevudine and entecavir for treatment-naïve patients with chronic hepatitis B: results after 2 years of treatment. Gwak GY, Eo SJ, Shin SR, Choi MS, Lee JH, Koh KC, Paik SW, Yoo BC.Hepatol Int. 2013 Mar;7(1):106-10. doi: 10.1007/s12072-012-9368-1. Epub 2012 Apr 24. PMID: 26201625
7:[Efficacy of entecavir switching therapy in chronic hepatitis B patients with clevudine-induced myopathy]. Lee JW, Lee YJ, Lee JJ, Kim JH, Jung YK, Kwon OS, Choi DJ, Kim YS, Kim JH.Korean J Gastroenterol. 2013 Jan 25;61(1):30-6. Korean. PMID: 23354347 Free Article
8:Long-term treatment outcomes of clevudine in antiviral-naive patients with chronic hepatitis B. Kim SB, Song IH, Kim YM, Noh R, Kang HY, Lee HIe, Yang HY, Kim AN, Chae HB, Lee SH, Kim HS, Lee TH, Kang YW, Lee ES, Kim SH, Lee BS, Lee HY.World J Gastroenterol. 2012 Dec 21;18(47):6943-50. doi: 10.3748/wjg.v18.i47.6943. PMID: 23322992 Free PMC Article
9:Mathematical modeling of triphasic viral dynamics in patients with HBeAg-positive chronic hepatitis B showing response to 24-week clevudine therapy. Kim HY, Kwon HD, Jang TS, Lim J, Lee HS.PLoS One. 2012;7(11):e50377. doi: 10.1371/journal.pone.0050377. Epub 2012 Nov 28. PMID: 23209728 Free PMC Article
10:Long-term treatment efficacy and safety of clevudine therapy in naïve patients with chronic hepatitis B. Choung BS, Kim IH, Jeon BJ, Lee S, Kim SH, Kim SW, Lee SO, Lee ST, Kim DG.Gut Liver. 2012 Oct;6(4):486-92. doi: 10.5009/gnl.2012.6.4.486. Epub 2012 Oct 18. PMID: 23170155 Free PMC Article
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