Neomycin sulfate

Form:Powder
Appearance:White or yellowish powder
Source:Streptomyces Fradiae.
Elemental Analysis:Sulphate: 27.0-31.0%
Impurity Profile:Impurity A| 2-deoxy-4-O-(2,6-diamino-2,6-dideoxy-d-glucopyranosyl)-d-streptamine (neamine or neomycin A-

Cat No:	A000999
Cas No:	1405-10-3
Product-Name:	Neomycin sulfate
IUPAC Name:	(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid
MDL No:	MFCD00077833
InChI:	1S/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22?,23+;/m1./s1
InChIKey:	OIXVKQDWLFHVGR-GQTDVWSESA-N
SMILES:	C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O

Neomycin sulfate (CAS 1405-10-3)  is the sulfate salt form of neomycin, which  is a broad spectrum aminoglycoside antibiotic composed of a number of related neomycin compounds including neomycin A (neamine), neomycin B (framycetin), neomycin C, and a few minor compounds found in much lower quantities.  Neomycin B is the most active component in neomycin followed by neomycin C and neomycin A.  The quantities of these components in neomycin vary from lot-to-lot.
Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.

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