Medroxyprogesterone Acetate

CAS No. : 71-58-9

Medroxyprogesterone Acetate,71-58-9
Product Details
Cat No:A000995
Synonyms:71-58-9; Medroxyprogesterone 17-acetate; Metigestrona; Provera; Depo-Provera
Molecular Formula:C24H34O4
Molecular Weight:386.52
Target:Estrogen/progestogen Receptor
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Appearance:Solid powder
Purity: > 98%
Cat No:A000995
Cas No:71-58-9
Product-Name:Medroxyprogesterone Acetate
Medroxyprogesterone Acetate, also known as MPA, is a steroidal progestin, a synthetic variant of the steroid hormone progesterone. It is used as a contraceptive, in hormone replacement therapy and for the treatment of endometriosis as well as several other indications. MPA is a more potent derivative of its parent compound medroxyprogesterone (MP). While medroxyprogesterone is sometimes used as a synonym for medroxyprogesterone acetate, what is almost always being referred to is MPA and not MP It is on the World Health Organization/'s List of Essential Medicines, the most important medication needed in a basic health system.
1: Polis CB, Achilles SL, Hel Z, Hapgood JP. Is a lower-dose, subcutaneous contraceptive injectable containing depot medroxyprogesterone acetate likely to impact women/'s risk of HIV? Contraception. 2017 Dec 11. pii: S0010-7824(17)30529-2. doi: 10.1016/j.contraception.2017.12.003. [Epub ahead of print] PubMed PMID: 29242082.
2: Yuasa-Shibasaki E, Ishii S, Matsumoto S, Tomaru T, Horiguchi K, Osaki A, Ozawa A, Shibusawa N, Satoh T, Yamada M. Hypercalcemia after the Discontinuation of Medroxyprogesterone Acetate. Intern Med. 2017 Dec 8. doi: 10.2169/internalmedicine.9036-17. [Epub ahead of print] PubMed PMID: 29225247.
3: Bartz D, Maurer R, Kremen J, Fortin JM, Janiak E, Goldberg AB. High-risk sexual behaviors while on depot medroxyprogesterone acetate as compared to oral contraception. Contracept Reprod Med. 2017 Jan 7;2:8. doi: 10.1186/s40834-016-0035-0. eCollection 2017. PubMed PMID: 29201413; PubMed Central PMCID: PMC5683469.
4: Tasker C, Davidow A, Roche NE, Chang TL. Depot medroxyprogesterone acetate administration alters immune markers for HIV preference and increases susceptibility of peripheral CD4(+) T cells to HIV infection. Immunohorizons. 2017 Nov 1;1(9):223-235. doi: 10.4049/immunohorizons.1700047. PubMed PMID: 29188238; PubMed Central PMCID: PMC5703073.
5: Roksvaag I, Skjeldestad FE. Decreasing trends in number of depot medroxyprogesterone acetate starters in Norway - a cross-sectional study. Acta Obstet Gynecol Scand. 2017 Nov 20. doi: 10.1111/aogs.13262. [Epub ahead of print] PubMed PMID: 29156102.
6: Tamauchi S, Kajiyama H, Utsumi F, Suzuki S, Niimi K, Sakata J, Mizuno M, Shibata K, Kikkawa F. Efficacy of medroxyprogesterone acetate treatment and retreatment for atypical endometrial hyperplasia and endometrial cancer. J Obstet Gynaecol Res. 2017 Nov 9. doi: 10.1111/jog.13473. [Epub ahead of print] PubMed PMID: 29121428.
7: Woods MW, Zahoor MA, Dizzell S, Verschoor CP, Kaushic C. Medroxyprogesterone acetate-treated human, primary endometrial epithelial cells reveal unique gene expression signature linked to innate immunity and HIV-1 susceptibility. Am J Reprod Immunol. 2018 Jan;79(1). doi: 10.1111/aji.12781. Epub 2017 Nov 6. PubMed PMID: 29105931.
8: Zhang J, Mao X, Wang Y, Chen Q, Lu X, Hong Q, Kuang Y. Neonatal outcomes and congenital malformations in children born after human menopausal gonadotropin and medroxyprogesterone acetate treatment cycles. Arch Gynecol Obstet. 2017 Dec;296(6):1207-1217. doi: 10.1007/s00404-017-4537-z. Epub 2017 Sep 25. PubMed PMID: 28948397.
9: Guo H, Wang Y, Chen Q, Chai W, Sun L, Ai A, Fu Y, Lyu Q, Kuang Y. Use of medroxyprogesterone acetate in women with ovarian endometriosis undergoing controlled ovarian hyperstimulation for in vitro fertilization. Sci Rep. 2017 Sep 20;7(1):11927. doi: 10.1038/s41598-017-12151-7. PubMed PMID: 28931865; PubMed Central PMCID: PMC5607235.
10: Kendall PD, Chen MJ. Case report of induced medical abortion following depot administration of medroxyprogesterone acetate. Int J Gynaecol Obstet. 2017 Dec;139(3):371-372. doi: 10.1002/ijgo.12303. Epub 2017 Sep 7. PubMed PMID: 28833078.
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