Form:PowderAppearance:White or almost white crystalline powderSource:Semi-syntheticWater Content (Karl Fisher):≤3.0%pH:8.0-10.0Optical Rotation:+240° to +290°Assay:(Dried Basis): ≥80.0%Impurities:Related SubstancesAmoxic
| Cat No: | A000865 |
| Cas No: | 34642-77-8 |
| Product-Name: | Amoxicillin Sodium |
Amoxicillin is an extended spectrum β-lactam antibiotic and is similar in structure to ampicillin. Resistance to amoxicillin can be attributed to β-lactamase enzymes secreted by a resistant cell.Like all β-lactams, amoxicillin targets PBP’s (penicillin binding proteins) involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised ultimately leading to the death of the cell.
Guzmán, Flavio, MD. /Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.
Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.
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