Aliskiren Hemifumarate

CAS No. : 173334-58-2

Aliskiren Hemifumarate,173334-58-2
Product Details
Cat No:A000605
Synonyms:(αS,γS,δS,zS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,z-bis(1-methylethyl)benzeneoctanamide Hemifumarate; CGP 60536; CGP60536B; Rasilez Hemifumarate; SPP 100; Tekturna Hemifumarate;
Molecular Formula:C₃₀H₅₃N₃O₆ • ½C₄H₄O₄
Molecular Weight:609.79
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Appearance:A crystalline solid
Cat No:A000605
Cas No:173334-58-2
Product-Name:Aliskiren Hemifumarate
MDL No:MFCD10566724
Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM.
Aliskiren hemifumarate appears to bind to both the hydrophobic S1/S3-binding pocket and to a large, distinct subpocket that extends from the S3-binding site towards the hydrophobic core of renin. Oral bioavailability of Aliskiren hemifumarate is 2.4% in rats, 16% in marmosets and about 2.5% in humans.
Aliskiren hemifumarate (< 10 mg/kg, oral) inhibits plasma renin activity and lowers blood pressure in sodium-depleted marmosets.
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